高尿酸血症在糖尿病周围神经病变发病机制中的研究进展

Research progress of hyperuricemia in the pathogenesis of diabetic peripheral neuropathy

糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病常见的慢性并发症之一,严重影响糖尿病患者生活质量,临床早期诊断对于DPN的防治至关重要。高尿酸血症是由嘌呤核苷酸代谢紊乱引起的代谢性疾病。尽管大量研究表明高尿酸血症可能是DPN的独立危险因素,但其对DPN的潜在影响和作用机制尚未完全阐明。本文对DPN的发病机制进行总结,并介绍了尿酸在DPN发病机制中的作用,阐述了高尿酸血症在DPN发病机制中氧化应激和炎症发挥的作用,旨在为后期寻找临床预警指标提供依据。

Diabetic peripheral neuropathy(DPN)is one of the common chronic complications of diabetes,which seriously affects the life quality of diabetic patients.Therefore,early clinical diagnosis is very important for the prevention and treatment of DPN.Hyperuricemia is a metabolic disease caused by purine nucleotide metabolism disorder.Although a large number of studies have shown that the hyperuricemia may be an independent risk factor for DPN,its potential effects on DPN and mechanisms of action have not been fully elucidated.This paper summarizes the pathogenesis of DPN,introduces the role of uric acid in the pathogenesis of DPN,and expounds that oxidative stress and inflammation are the roles of hyperuricemia in the pathogenesis of DPN,so as to provide references for finding early clinical warning indicators.