妊娠期糖尿病患者炎症因子、FA和Vit B-12水平检测及临床意义分析

Detection and Clinical Significance Analysis of Inflammatory Factors,FA and Vit B-(12)Levels in Patients with Gestational Diabetes Mellitus

目的研究分析妊娠期糖尿病患者炎症因子、叶酸(Folic Acid,FA)、维生素B12(Vitamin B-12,Vit B-12)的检测结果。方法回顾性选取2020年1月—2022年1月福清市妇幼保健院的60例妊娠期糖尿病患者的临床资料为观察组,同期60例健康孕妇的临床资料为对照组。两组均行疾病指标(空腹血糖、空腹胰岛素)、炎症因子[C反应蛋白(C-reactive Protein,CRP)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、白介素-6(Interleukin-6,IL-6)、同型半胱氨酸(Homocysteine,HCY)]、FA、Vit B-12检测,比较两组检测结果差异,分析上述指标的临床意义。结果观察组空腹血糖、空腹胰岛素、血清CRP、TNF-α、IL-6、HCY水平较对照组高,观察组FA、Vit B-12水平较对照组低,差异有统计学意义(P均<0.05)。高HCY亚组患者的FA、Vit B-12较低HCY亚组低,差异有统计学意义(P均<0.05)。妊娠期糖尿病患者的HCY与FA、Vit B-12呈负相关性(r=-0.598、-0.617,P均<0.05)。结论妊娠期糖尿病患者病发后有明显的炎症因子水平上升、FA和Vit B-12水平下降现象,其中患者HCY水平的上升与FA、Vit B-12水平的下降明显相关。

Objective To analyze the detection results of inflammatory factors,folic acid(FA),and vitamin B-12(Vit B-12)in gestational diabetes mellitus patients.Methods The clinical data of 60 gestational diabetes patients in Fuq-ing Maternal and Child Health Hospital from January 2020 to January 2022 was retrospective selected as the observa-tion group,and the clinical data of 60 healthy pregnant women at the same time period was selected as the control group.Disease indicators(fasting blood glucose,fasting insulin),inflammatory factors[C-reactive protein(CRP),tu-mor necrosis factor-α(TNF-α),interleukin-6(IL-6),homocysteine(HCY)],FA and Vit B-12 were detected in both groups.The difference between the two groups was compared,and the clinical significance of the above indexes was analyzed.Results The levels of fasting blood glucose and fasting insulin,serum CRP,TNF-α,IL-6 and HCY in ob-servation group were higher than those in control group,and the levels of FA and Vit B-12 in the observation group were lower than those in the control group,the differences were statistically significant(all P<0.05).The FA and Vit B-12 levels in high HCY subgroup were lower than those in low HCY subgroup,and the differences were statistically significant(both P<0.05).There was a negative correlation between HCY and FA,Vit B-12 in gestational diabetes mellitus(r=-0.598,-0.617,both P<0.05).Conclusion After the onset of gestational diabetes mellitus,the levels of in-flammatory factors increased significantly,and the levels of FA and Vit B-12 decreased significantly,among which the increase of HCY level was significantly correlated with the decrease of FA and Vit B-12 levels.