糖化血红蛋白与血脂检测在2型糖尿病中的意义研究

Significance of Glycosylated Hemoglobin and Blood Lipid Detection in Type 2 Diabetes Mellitus

目的分析糖化血红蛋白与血脂检测在2型糖尿病中的意义。方法回顾性选取2021年8月—2023年8月京山市人民医院收治的166例2型糖尿病患者(研究组)和同期来本院的166例健康体检者(对照组)的临床资料,对比两组糖化血红蛋白与血脂指标。将2型糖尿病患者以糖化血红蛋白水平不同分为3组,高水平(<6.9%,55例)、中水平(6.9%~10%,56例)和低水平(>10%,55例),对比不同水平患者的血脂指标及相关性。结果研究组糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白水平均明显高于对照组,高密度脂蛋白水平明显低于对照组,差异有统计学意义(P均<0.05)。高水平患者的总胆固醇、三酰甘油、低密度脂蛋白均明显高于中、低水平者,高密度脂蛋白明显低于中、低水平者,3组间比较,差异有统计学意义(P均<0.05)。糖化血红蛋白与血脂指标具有相关性,与总胆固醇、三酰甘油、低密度脂蛋白成正比(r=0.765,0.678,0.861),与高密度脂蛋白成反比(r=-0.567)。结论糖化血红蛋白与血脂检测可用于评估2型糖尿病发病风险,糖化血红蛋白与血脂指标具有相关性。

Objective To analyze the significance of glycosylated hemoglobin and blood lipid detection in type 2 dia-betes.Methods The clinical data of 166 patients with type 2 diabetes admitted to Jingshan People's Hospital from Au-gust 2021 to August 2023(study group)and 166 healthy subjects admitted to our hospital during the same period(con-trol group)were retrospectively selected.The HbA1c and lipid indexes of the two groups were compared.The patients with type 2 diabetes were divided into 3 groups according to different levels of HbA1c.High level(<6.9%,55 cases),medium level(6.9%~10%,56 cases)and low level(>10%,55 cases).The blood lipid indexes and correlation of pa-tients with different levels were compared.Results The levels of glycosylated hemoglobin,total cholesterol,triglycer-ide and low density lipoprotein in the study group were significantly higher than those in the control group,and the levels of high density lipoprotein was significantly lower than that in the control group,and the differences were statis-tically significant among the three groups(all P<0.05).The total cholesterol,triglyceride and low density lipoprotein of high level patients were significantly higher than those of medium and low level patients,and high density lipoprotein was significantly lower than those of medium and low level patients,and the differences were statistically significant among the three groups(all P<0.05).HbA1c was correlated with lipid index,and was directly proportional to total cho-lesterol,triglyceride and low density lipoprotein(r=0.765,0.678,0.861),and inversely proportional to high density li-poprotein(r=-0.567).Conclusion Hba1c and lipid levels can be used to assess the risk of type 2 diabetes.Glycosyl-ated hemoglobin and lipid levels are correlated.