利拉鲁肽对小切口阑尾切除术治疗急性阑尾炎合并T2DM患者血糖、脂联素及胰岛素的影响

Effects of Liraglutide on Blood Glucose,Adiponectin and Insulin in Patients with Acute Appendicitis and T2DM Treated with Small Incision Appendectomy

目的探讨利拉鲁肽对急性阑尾炎合并2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者采用小切口阑尾切除术对血糖、脂联素及胰岛素的影响。方法选取2019年12月—2021年12月厦门前埔医院收治的96例急性阑尾炎合并T2DM患者为研究对象,采用随机抽签法分为对照组(n=48)、观察组(n=48)。两组均接受小切口阑尾切除术,对照组术后采用二甲双胍治疗,观察组术后采用利拉鲁肽治疗,两组患者的疗程均为2周。比较两组治疗前、治疗2周后空腹血糖(Fasting Plasma Glucose,FPG)、餐后2 h血糖(2-Hour Postprandial Glu-cose,2 hPG)、糖化血红蛋白(Glycosylated Hemoglobin A1c,HbA1c)、胰岛β细胞分泌指数(Homeostasis Model Assessment-β,HOMA-β)、空腹胰岛素(Fasting Insulin,FNIS)、胰岛素抵抗指数(Homeostatic Model Assess-ment for Insulin Resistance,HOMA-IR)水平。结果观察组治疗2周后的血糖指标及HOMA-IR水平均低于对照组,脂联素、HOMA-β、FNIS水平高于对照组,差异有统计学意义(P均<0.05)。结论利拉鲁肽能降低急性阑尾炎合并T2DM小切口阑尾切除术患者的血糖水平,提高脂联素水平,改善胰岛素分泌和抵抗。

Objective To investigate the effects of liraglutide on blood glucose,adiponectin and insulin in patients with acute appendicitis complicated with type 2 diabetes mellitus(T2DM)after small incision appendectomy.Methods 96 patients with acute appendicitis combined with T2DM received at Xiamen Qianpu Hospital from December 2019 to December 2021 were selected as the study objects,and they were divided into the control group(n=48)and the observation group(n=48)by randomized lottery method.Both groups underwent small incision appendectomy.The control group was treated with metformin after surgery,and the observation group was treated with liraglutide after surgery.Fasting Plasma Glucose(FPG),2-hour Postprandial Glucose(2 hPG),Glycosylated Hemoglobin A1c(HbA1c),Homeostasis Model Assessment-β(HOMA-β)were compared between the two group.Results The blood glucose indexes and HOMA-IR levels of the observation group after 2 weeks of treatment were lower than those of the control group,and the levels of lipocalin,HOMA-β,and FNIS were higher than those of the control group,and the dif-ferences were statistically significant(all P<0.05).Conclusion Liraglutide can decrease blood glucose level,increase adiponectin level,and improve insulin secretion and resistance in patients with acute appendicitis complicated with T2DM mini-incision appendectomy.