伏诺拉生联合阿莫西林治疗Hp感染的效果及对胃黏膜组织形态学的影响

Effect of Venolazan Combined with Amoxicillin in the Treatment of Hp In⁃fection and Its Effect on Gastric Mucosal Histomorphology

目的分析伏诺拉生联合阿莫西林治疗幽门螺杆菌(Helicobocton Pyloni,Hp)感染的效果。方法随机选取2022年4月—2023年3月福州经济技术开发区医院收治的200例Hp感染患者为研究对象,通过随机抽签法分为两组,各100例。对照组给予艾司奥美拉唑+枸橼酸铋钾+克拉霉素+阿莫西林治疗,观察组给予伏诺拉生+枸橼酸铋钾+克拉霉素+阿莫西林治疗,比较两组整体效果。结果对照组的Hp根除率为90.00%,低于观察组的98.00%,差异有统计学意义(χ^(2)=5.674,P<0.05)。治疗后,对照组胃黏膜炎症细胞浸润、黏膜厚度、腺体形态、腺体密度评分均高于观察组,差异有统计学意义(P均<0.05)。治疗后,对照组白细胞介素-4、一氧化氮低于观察组,白细胞介素-2、白细胞介素-32、转化生长因子-β1高于观察组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论伏诺拉生联合阿莫西林治疗Hp感染,可提升对Hp的根除率,促使胃黏膜组织形态学恢复,缓解炎性反应,效果理想。

Objective To analyze the effect of venolazan combined with amoxicillin on Helicobacter pylori(Hp)infec-tion.Methods A total of 200 patients with Hp infection admitted to Fuzhou Economic and Technological Development Zone Hospital from April 2022 to March 2023 were randomly selected as the study objects,and were divided into two groups with 100 patients in each group by random drawing method.Control group was given esomeprazole+bismuth potassium citrate+clarithromycin+amoxicillin treatment.Observation group was given venolazan+bismuth potassium citrate+clarithromycin+amoxicillin treatment.The overall effect of the two groups was compared.Results The eradi-cation rate of Hp was 90.00%in the control group,which was lower than 98.00%in the observation group,the differ-ence was statistically significant(χ^(2)=5.674,P=0.017).After treatment,the scores of gastric mucosal inflammatory cell infiltration,mucosal thickness,glandular morphology and glandular density in control group were higher than those in observation group,the differences were statistically significant(all P<0.05).After treatment,interleukin-4 and nitric oxide in control group were lower than those in observation group,Interleukin-2,interleukin-32 and transforming growth factor-β1 were higher than those in observation group,the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of Hp infection,venolazan combined with amoxicillin can improve the eradication rate of Hp,promote the recovery of gastric mucosa histomorphology,and alleviate inflammatory response,with ideal effect.