阿托西班联合宫颈环扎术治疗先兆早产的临床疗效及对母婴结局的影响

Clinical Effect of Atosiban Combined with Cervix Ligature in the Treat⁃ment of Threatened Premature Delivery and Its Influence on Maternal and Infant Outcomes

目的探讨阿托西班联合宫颈环扎术在临床上治疗先兆早产中的效果及其对母婴健康结局的影响。方法回顾性选取2020年7月—2023年8月福建医科大学附属南平第一医院收治的90例先兆早产孕妇的临床资料。根据宫缩抑制剂的使用情况分为对照组和观察组(每组45例),其中观察组使用阿托西班联合宫颈环扎术治疗,对照组使用盐酸利托君联合宫颈环扎术,对比两组妊娠延长时间、分娩结局情况、新生儿出生情况、术后不良反应。结果治疗后,观察组妊娠延长时间为(19.72±2.54)d,明显高于对照组的(17.13±2.51)d,差异有统计学意义(t=-4.870,P<0.05)。观察组足月产率高于对照组,差异有统计学意义(P<0.05)。两组早产率和流产率比较,差异无统计学意义(P均>0.05)。两组新生儿出生体质量比较,差异无统计学意义(P>0.05)。观察组新生儿Apgar评分高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论阿托西班与宫颈环扎术相结合在治疗先兆早产方面展现出良好的临床效果,能够有效延长早产患者的妊娠时间,提高患者的足月分娩率,从而改善妊娠结局。

Objective To investigate the clinical effect of atosiban combined with cervix ligature in the treatment of threatened premature delivery and its influence on maternal and infant health outcomes.Methods The clinical data of 90 pregnant women with threatened preterm birth admitted to Nanping First Hospital Affiliated to Fujian Medical Uni-versity from July 2020 to August 2023 were retrospectively selected.According to the use of uterine contraction inhibi-tors,they were divided into control group and observation group(45 cases in each group),in which the observation group was treated with atosiban combined with cervical cervix,and the control group was treated with ritodrine hydro-chloride combined with cervical cervix.The pregnancy extension time,delivery outcomes,newborn birth and postop-erative adverse reactions were compared between the two groups.Results After treatment,the prolongation of preg-nancy in the observation group was(19.72±2.54)d,which was significantly higher than that in the control group[(17.13±2.51)d],and the difference was statistically significant(t=-4.870,P<0.05).The term birth rate of the observa-tion group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in preterm birth rate and abortion rate between the two groups(both P>0.05).There was no significant difference in birth weight between the two groups(P>0.05).The Apgar score in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no signifi-cant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combina-tion of atosiban and cervix ligature has shown good clinical effect in the treatment of threatened preterm delivery,which can effectively prolong the gestation time of preterm delivery patients,increase the rate of full-term delivery of patients,and improve the pregnancy outcome.