氨甲环酸联合卡前列素氨丁三醇与卡贝缩宫素治疗前置胎盘产后出血的临床效果分析

Clinical Effect of Tranexamic Acid Combined with Carprost Tramine and Carbetocin on Postpartum Hemorrhage of Placenta Previa

目的分析前置胎盘产后出血采用氨甲环酸联合卡前列素氨丁三醇与卡贝缩宫素的治疗效果。方法方便选取于2021年1月—2023年6月沭阳县中医院治疗的72例前置胎盘产后出血患者为研究对象,以随机数表法分为研究组和对照组,各36例。研究组实施氨甲环酸联合卡前列素氨丁三醇与卡贝缩宫素治疗,对照组实施卡前列素氨丁三醇与卡贝缩宫素治疗,对比两组治疗总有效率、不良反应发生率和止血效果等指标。结果研究组患者的治疗总有效率为97.22%,高于对照组的77.78%,差异有统计学意义(χ^(2)=4.571,P<0.05);研究组不良反应发生率为5.56%,低于对照组的22.22%,差异有统计学意义(χ^(2)=4.181,P<0.05);研究组止血时间、产后2 h出血量、产后4 h出血量分别(20.95±2.24)min、(51.41±5.32)mL、(151.08±10.29)mL,均优于对照组,差异有统计学意义(t=56.323、24.689、39.541,P均<0.05)。结论对前置胎盘产后出血患者在进行临床治疗时采用氨甲环酸联合卡前列素氨丁三醇与卡贝缩宫素治疗,可取得更好的治疗效果,不良反应发生绿较低,止血效果更快,患者出血量更少。

Objective To analyse the effect of tranexamic acid combined with carprost tramine and carbetocin in post-partum hemorrhage of placenta previa.Methods A total of 72 patients with postpartum hemorrhage of placenta previa treated in Shuyang County Hospital of Traditional Chinese Medicine from January 2021 to June 2023 were conve-niently selected as the study objects and divided into study group and control group by random number table method,with 36 cases in each group.The study group was treated with tranexamic acid combined with carprost tramine and carbetocin,while the control group was treated with carprost tramine and carbetocin.The total effective rate,incidence of adverse reactions and hemostatic effect were compared between the two groups.Results The total effective rate of the study group was 97.22%,which was higher than that of the control group(77.78%),and the difference was statisti-cally significant(χ^(2)=4.571,P<0.05).The incidence of adverse reactions in the study group was 5.56%lower than that in the control group(22.22%),and the difference was statistically significant(χ^(2)=4.181,P<0.05).The hemostatic time,postpartum blood loss at 2 hours and 4 hours in the study group were(20.95±2.24)min,(51.41±5.32)mL and(151.08±10.29)mL,respectively,which were better than those in the control group,and the differences were statistically signifi-cant(t=56.323,24.689,39.541,all P<0.05).Conclusion In the selection of clinical treatment plan for patients with placenta previa postpartum hemorrhage,tranexamic acid combined with carprost tramine and carbetocin can achieve better treatment effect,lower adverse reactions incidence,faster hemostatic effect,and less blood loss for patients.