血清FOLR1、IL-1β及SMRP联合检测在上皮性卵巢癌早期诊断中的价值

Value of Combined Detection of Serum FOLR1,IL-1βand SMRP in the Early Diagnosis of Epithelial Ovarian Cancer

目的分析血清叶酸受体-1(FOLR1)、白细胞介素-1(IL-1β)及可溶性间皮素相关蛋白(SMRP)联合检测在上皮性卵巢癌早期诊断中的价值。方法回顾性分析150例卵巢肿瘤患者的临床资料,以术后病理诊断结果为金标准,根据良恶性情况将其分为上皮性卵巢癌组(n=84)和非上皮性卵巢癌组(n=66)。比较2组入院时血清FOLR1、IL-1β、SMRP水平,采用ROC曲线分析入院时血清FOLR1、IL-1β、SMRP及联合检测对上皮性卵巢癌的早期诊断效能。根据上皮性卵巢癌组患者临床分期标准将其分为Ⅰ期组(n=12)、Ⅱ期组(n=27)、Ⅲ期组(n=31)、Ⅳ期组(n=14)4个亚组,比较不同临床分期的上皮性卵巢癌患者入院时血清FOLR1、IL-1β、SMRP水平差异。结果上皮性卵巢癌组患者入院时血清FOLR1、IL-1β、SMRP水平均高于非上皮性卵巢癌组(P<0.05)。入院时血清FOLR1、IL-1β、SMRP及其联合检测曲线均明显高于参考线(P<0.05),其cut off值分别为325.94 pg/ml、11.78 pg/ml、3.28 pg/ml。上皮性卵巢癌组患者入院时血清FOLR1、IL-1β、SMRP水平随临床分期升高而升高,且差异均有统计学意义(P<0.05)。结论入院时患者血清FOLR1、IL-1β及SMRP联合检测在上皮性卵巢癌早期诊断中具有一定临床诊断价值,血清FOLR1、IL-1β、SMRP水平越高,说明卵巢肿瘤癌变情况越严重。临床治疗可根据血清FOLR1、IL-1β、SMRP水平提前采取治疗措施,以避免肿瘤进一步癌变。

Objective To analyze the value of combined detection of serum folate receptor-1(FOLR1),interleukin-1(IL-1β)and soluble mesothelin-related protein(SMRP)in the early diagnosis of epithelial ovarian cancer.Methods The clinical data of 150 patients with ovarian tumors were retrospectively analyzed.With the postoperative pathological diagnosis result as the gold standard,the patients were divided into epithelial ovarian cancer group(n=84)and non-epithelial ovarian cancer group(n=66)according to benign and malignant conditions,and serum FOLR1,IL-1β and SMRP levels at admission were compared between the 2 groups.ROC curve was used to analyze the early diagnostic efficiency of serum FOLR1,IL-1β,SMRP at admission and combined detection on epithelial ovarian cancer.According to the clinical staging criteria,the patients in epithelial ovarian cancer group were classified into stage Ⅰ group(n=12),stage Ⅱ group(n=27),stage Ⅲ group(n=31)and stageⅣgroup(n=14).The differences in serum levels of FOLR1,IL-1β,and SMRP were compared among patients with epithelial ovarian cancer of different clinical stages.Results The levels of serum FOLR1,IL-1β and SMRP at admission in epithelial ovarian cancer group were higher than those in non-epithelial ovarian cancer group(P<0.05).The curves of serum FOLR1,IL-1β,SMRP at admission and combined detection were significantly higher than the reference line(P<0.05),and their cut off values were 325.94 pg/ml,11.78 pg/ml and 3.28 pg/ml respectively.The levels of serum FOLR1,IL-1β and SMRP at admission in epithelial ovarian cancer group were increased with the increase of clinical stage(P<0.05).Conclusion The combined detection of serum FOLR1,IL-1β and SMRP at admission has certain clinical diagnostic value in the early diagnosis of epithelial ovarian cancer.The higher the levels of serum FOLR1,IL-1β and SMRP,the more serious the ovarian cancer.In clinical treatment,it is feasible to take treatment measures in advance according to serum FOLR1,IL-1β and SMRP levels so as to avoid further further canceration of tumor.