摘要
A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling reagents.Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.
基金
supported the Natural Science Foundation of Higher Education Institutions in Anhui Province(2022AH030133,2022AH051340)
National Natural Science Foundation of China(22231003,22271008)
Shenzhen Science and Technology Program(Grant No.KQTD20190929174023858)
Shenzhen Science and Technology Innovation Committee(GXWD20201231165807007-20200812100115001)
Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2023SHIBS0004)
Horizontal Cooperation Project of Fuyang Municipal Government(SXHZ202201)
Key Projects of the Support Program for Outstanding Young Talents in Anhui Province Colleges and Universities(gxyqZD2020030)
Yifan Pharmaceutical Co.,Ltd.(HX2019033)
Innovative Drug Design&Development Collaborative Team(TDYY2021009).