不同世界卫生组织胸腺瘤组织学分类和Masaoka-Koga分期胸腺瘤患者的临床病理特征差异分析

Analysis of Differences in Clinicopathological Characteristics of Thymoma Patients According to Different World Health Organization Histological Classifications of Thymic and Masaoka-Koga Stages

目的:分析不同世界卫生组织胸腺瘤组织学分类(简称WHO分型)和Masaoka-Koga分期胸腺瘤患者的临床病理特征差异。方法:回顾性分析2012年3月—2023年12月于贺州市人民医院行手术治疗的48例胸腺瘤患者的病历资料。比较不同WHO分型和Masaoka-Koga分期胸腺瘤患者临床特征的差异,采用Spearman相关系数分析其相关性。结果:48例胸腺瘤患者中良性12例,恶性36例,其中A型3例,AB型9例,B1型12例,B2型15例,B3型5例,B2-B3混合型4例。不同WHO分型患者年龄、性别、症状发生率、发病部位、肿瘤直径比较,差异无统计学意义(P>0.05);恶性患者Ki-67≤10%占比大于良性患者,差异有统计学意义(P=0.040)。48例胸腺瘤患者中早期35例,晚期13例,其中Ⅰ期7例,Ⅱ期28例,Ⅲ期7例,Ⅳ期6例。不同Masaoka-Koga分期患者年龄、性别、症状发生率、发病部位、Ki-67水平比较,差异无统计学意义(P>0.05);晚期患者肿瘤直径>8 cm占比大于早期患者,差异有统计学意义(P=0.020)。Spearman相关分析显示,胸腺瘤患者Masaoka-Koga分期与肿瘤直径呈正相关(r=0.337,P=0.019),WHO分型与Masaoka分期呈正相关(r=0.407,P=0.004)。结论:胸腺瘤患者Masaoka-Koga分期与肿瘤直径、WHO分型均呈正相关,可通过以上参数评估胸腺瘤恶性程度,为临床治疗胸腺瘤提供参考。

Objective:To analyze the clinicopathological characteristics of thymoma patients with different histological classification of thymic Pain from World Health Organization(WHO)and Masaoka-Koga stage.Methods:The data of 48 patients with thymoma who underwent surgical treatment in Hezhou People's Hospital were retrospectively analyzed from March 2012 to December 2023.The clinical characteristics of thymoma patients with different WHO types and Masaoka-Koga stages were compared,and the correlation was analyzed by Spearman correlation coefficient.Results:Among 48 patients with thymoma,12 were benign and 36 were malignant,including 3 cases of type A,9 cases of type AB,12 cases of type B1,15 cases of type B2,5 cases of type B3 and 4 cases of mixed type B2-B3.There was no significant difference in age,gender,incidence of symptoms,location of disease and tumor diameter among patients classified by WHO(P>0.05).The proportion of Ki-67≤10%in malignant patients was higher than that in benign patients,and the difference was statistically significant(P=0.040).Among the 48 patients with thymoma,35 cases were early stage,13 cases were late stage,including 7 cases of stageⅠ,28 cases of stageⅡ,7 cases of stageⅢ,and 6 cases of stageⅣ.There was no significant difference in age,gender,incidence of symptoms,location of disease and Ki-67 level among Masaoka-Koga stage patients(P>0.05).The proportion of tumor diameter>8 cm in advanced patients was higher than that in early patients,and the difference was statistically significant(P=0.020).Spearman correlation analysis showed that Masaoka-Koga stage of thymoma patients was positively correlated with tumor diameter(r=0.337,P=0.019),and WHO classification was positively correlated with Masaoka stage(r=0.407,P=0.004).Conclusion:Masaoka-Koga stage of thymoma patients is positively correlated with tumor diameter and WHO classification.The above parameters can be used to evaluate the malignant degree of thymoma,and provide reference for clinical treatment of thymoma.