妊娠中晚期羊水过少患者应用低分子肝素的临床效果分析

Clinical Effect Analysis of Low Molecular Weight Heparin in Patients with Oligohydramnios in Middle and Late Pregnancy

目的:分析低分子肝素治疗妊娠中晚期羊水过少的临床效果。方法:选取2019年6月—2023年7月惠州市第一人民医院和惠州市中心医院收治的妊娠中晚期羊水过少患者60例作为研究对象,随机分为对照组和观察组,各30例。对照组采用常规静脉补液治疗,观察组在对照组基础上联合低分子肝素治疗。比较两组分娩方式、脐动脉血流阻力(S/D)、羊水指数(AFI)、新生儿阿普加(Apgar)评分、不良妊娠结局发生情况。结果:观察组自然分娩率高于对照组,差异有统计学意义(P=0.009)。治疗前,两组S/D、AFI水平比较,差异无统计学意义(P>0.05);治疗后,两组S/D水平低于治疗前,且观察组低于对照组,两组AFI水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组Apgar评分高于对照组,差异有统计学意义(P<0.001)。观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P=0.005)。结论:妊娠中晚期羊水过少患者采用低分子肝素治疗的效果较好,可提高患者自然分娩率,改善S/D、AFI水平,提高新生儿Apgar评分,降低不良妊娠结局发生率。

Objective:To analyze the clinical effect of low molecular weight heparin in the treatment of oligohydramnios in middle and late pregnancy.Methods:A total of 60 patients with oligohydramnios in middle and late pregnancy were selected as the study objects at Huizhou First People's Hospital and Huizhou Central Hospital from June 2019 to July 2023,and were randomly divided into control group and observation group,with 30 patients in each group.The control group was treated with conventional intravenous fluid replenishment,and the observation group was treated with low molecular weight heparin on the basis of control group.Mode of delivery,umbilical artery flow resistance(S/D),amniotic fluid index(AFI),neonatal Apgar score and adverse pregnancy outcomes were compared between the two groups.Results:The natural delivery rate in the observation group was higher than that in the control group,the difference was statistically significant(P=0.009).Before treatment,there was no significant difference in S/D and AFI levels between the two groups(P>0.05).After treatment,the S/D level of the two groups was lower than before treatment,and the observation group was lower than the control group,and the AFI level of the two groups was higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).The Apgar score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.001).The incidence of adverse pregnancy outcome in observation group was lower than that in control group,and the difference was statistically significant(P=0.005).Conclusion:Low molecular weight heparin therapy can improve the natural delivery rate,improve S/D and AFI levels,increase neonatal Apgar score,and reduce the incidence of adverse pregnancy outcomes.