地氯雷他定与氯雷他定治疗慢性特发性荨麻疹的临床效果分析

Clinical Effects of Desloratadine and Loratadine in the Treatment of Chronic Idiopathic Urticaria

目的:探讨地氯雷他定与氯雷他定治疗慢性特发性荨麻疹的临床效果。方法:选取2021年1月—2023年12月临沂市中医医院收治的慢性特发性荨麻疹患者104例作为研究对象,采用随机数字表法分为观察组与对照组,各52例。对照组接受氯雷他定治疗,观察组接受地氯雷他定治疗。比较两组治疗效果、不良反应发生情况、满意度、起效时间。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.028);两组不良反应总发生率比较,差异无统计学意义(P>0.05);观察组总满意度高于对照组,差异有统计学意义(P=0.008);两组治疗起效时间比较,差异无统计学意义(P>0.05)。结论:地氯雷他定治疗慢性特发性荨麻疹效果优于氯雷他定,患者满意度更高,且未增加不良反应发生风险,未延长治疗起效时间。

Objective:To investigate the clinical effect of desloratadine and loratadine in the treatment of chronic idiopathic urticaria.Methods:A total of 104 patients with chronic idiopathic urticaria were selected as the study objects at Linyi Hospital of Traditional Chinese Medicine from January 2021 to December 2023,and were divided into observation group and control group by random number table method,with 52 cases in each group.The control group received loratadine treatment,and the observation group received desloratadine treatment.The therapeutic effect,occurrence of adverse reactions,satisfaction and onset time were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.028).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The total satisfaction of observation group was higher than that of control group,the difference was statistically significant(P=0.008).There was no significant difference in treatment onset time between the two groups(P>0.05).Conclusion:Desloratadine is more effective than loratadine in the treatment of chronic idiopathic urticaria,with higher patient satisfaction,and does not increase the risk of adverse reactions,and does not prolong the treatment onset time.