百令胶囊联合大黄碳酸氢钠片治疗尿毒症维持血液透析患者临床研究

Clinical Study on Bailing Capsules Combined with Rhubarb and Sodium Bicarbonate Tablets for Patients with Uremia Undergoing Hemodialysis

目的:观察百令胶囊联合大黄碳酸氢钠片治疗对尿毒症维持血液透析患者血管内皮功能及微炎症因子水平的影响。方法:选取尿毒症行血液透析患者60例,随机分为对照组和试验组各30例。对照组给予大黄碳酸氢钠片联合碳酸钙片治疗,试验组采用百令胶囊联合大黄碳酸氢钠片治疗。治疗4周后,比较2组治疗前后中医证候评分、血管内皮功能指标[血管内皮生长因子(VEGF)、血浆内皮素-1(ET-1)]、微炎症细胞因子指标[C-反应蛋白(CRP)、白细胞介素-8(IL-8)]变化。结果:治疗前,2组中医证候主、次症评分比较,差异均无统计学意义(P>0.05);治疗后,2组中医证候主、次症评分均较治疗前降低(P<0.05),且试验组主、次症评分均低于对照组(P<0.05)。治疗前,2组ET-1、VEGF水平比较,差异无统计学意义(P>0.05);治疗后,2组VEGF、ET-1水平均较治疗前降低(P<0.05),且试验组VEGF、ET-1水平均低于对照组(P<0.05)。治疗前,2组CRP、IL-8水平比较,差异无统计学意义(P>0.05);治疗后,2组CRP、IL-8水平均较治疗前降低(P<0.05),且试验组CRP、IL-8水平均低于对照组(P<0.05)。结论:百令胶囊联合大黄碳酸氢钠片辅助治疗尿毒症维持血液透析患者,有利于改善其临床症状及血管内皮功能,降低机体微炎症因子水平。

Objective:To observe the effects of Bailing Capsules combined with Rhubarb and Sodium Bicarbonate Tablets on the vascular endothelial function and levels of micro-inflammatory factors in patients With uremia undergoing hemodialysis.Methods:A total of 60 cases of patients with uremia undergoing hemodialysis were randomly divided into the control group and the trial group,with 30 cases in each group.The control group was treated with Rhubarb and Sodium Bicarbonate Tablets combined with Calcium Carbonate Tablets,and the trial group was treated with Bailing Capsules combined with Rhubarb and Sodium Bicarbonate Tablets.After 4 weeks of treatment,the changes in traditional Chinese medicine(TCM)syndrome scores,vascular endothelial function indexes[vascular endothelial growth factor(VEGF),and plasma endothelin-1(ET-1)]and micro-inflammatory factors[C-reactive protein(CRP),and interleukin-8(IL-8)]were compared before and after treatment between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of the scores of primary and secondary symptoms of TCM syndromes between the two groups(P>0.05).After treatment,the scores of primary and secondary symptoms of TCM syndromes in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the trial group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of ET-1 and VEGF between the two groups(P>0.05).After treatment,the levels of VEGF and ET-1 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of VEGF and ET-1 in the trial group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of CRP and IL-8 between the two groups(P>0.05).After treatment,the levels of CRP and IL-8 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of CRP and IL-8 in the trial group were lower than those in the control group(P<0.05).Conclusion:The ajuvant treatment of Bailing Capsules combined with Rhubarb and Sodium Bicarbonate Tablets for patients with uremia undergoing hemodialysis can improve their clinical symptoms and vascular endothelial function,and reduce the levels of micro-inflammatory factors.