白细胞介素-6、白细胞介素-8、γ干扰素、肿瘤坏死因子-α联合检测对腹腔镜下胃癌根治术后并发肺炎的预测价值

Predictive value of combined detection of interleukin 6,interleukin,8,interferon-γ and tumor necrosis factor-α for pneumonia after laparoscopic radical gastrectomy

目的分析白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、γ干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)联合检测对腹腔镜下胃癌根治术后并发肺炎的预测价值。方法将72例胃癌患者按术后是否并发肺炎分为观察组(并发肺炎)30例和对照组(未并发肺炎)42例。比较两组患者血清IL-6、IL-8、IFN-γ、TNF-α水平,绘制受试者工作特征(ROC)曲线,分析血清IL-6、IL-8、IFN-γ、TNF-α单独及联合检测对腹腔镜下胃癌根治术后并发肺炎的预测价值。结果观察组患者血清IL-6、IL-8、IFN-γ、TNF-α水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。血清IL-6、IL-8、IFN-γ、TNF-α联合检测预测腹腔镜下胃癌根治术后并发肺炎的灵敏度(94.85%)高于各指标单独检测(75.12%、71.86%、69.82%、72.84%)。结论腹腔镜下胃癌根治术后并发肺炎患者血清IL-6、IL-8、IFN-γ、TNF-α水平异常升高,联合检测可提高对肺炎的预测灵敏度,具有一定参考价值。

Objective To analyze the predictive value of combined detection of interleukin-6(IL-6),interleukin-8(IL-8),interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α)for pneumonia after laparoscopic radical gastrectomy.Method A total of 72 patients with gastric cancer were divided into observation group(complicated with pneumonia,n=30)and control group(without pneumonia,n=42)based on whether developed pneumonia after surgery.The levels of se-rum IL-6,IL-8,IFN-γand TNF-αin the two groups were compared,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum IL-6,IL-8,IFN-γand TNF-αsingle and combined detection for pneumonia after laparoscopic radical gastrectomy.Result The levels of serum IL-6,IL-8,IFN-γand TNF-αin the ob-servation group were significantly higher than those in the control group,the differences were statistically significant(P<0.01).The sensitivity(94.85%)of combined detection of serum IL-6,IL-8,IFN-γand TNF-αin predicting pneumonia af-ter laparoscopic radical gastrectomy was higher than that of single detection(75.12%,71.86%,69.82%,72.84%).ConcluConclu-sion The levels of serum IL-6,IL-8,IFN-γand TNF-αin patients with pneumonia after laparoscopic radical gastrecto-my are abnormally increased,and combined detection can improve the predictive sensitivity of pneumonia,which has cer-tain reference value.