应重视自主神经功能障碍在中枢性α‑突触核蛋白病诊断与预后预测中的作用

Pay attention to the value of autonomic dysfunction in diagnosing and prognosis prediction of centralα⁃synucleinopathy

中枢性α‑突触核蛋白病包括帕金森病、路易体痴呆和多系统萎缩,上述疾病的临床表现部分重叠,鉴别诊断较为困难。自主神经功能障碍是这些疾病的共同常见特征,对自主神经功能障碍的研究有助于进一步理解中枢性α‑突触核蛋白病。本文对上述3种疾病自主神经功能障碍在疾病早期诊断、鉴别诊断和预后预测方面的应用价值进行梳理,以指导临床诊断与治疗。

Centralα‑synucleinopathy includes Parkinson's disease(PD),dementia with Lewy bodies(DLB)and multiple system atrophy(MSA).The clinical manifestations of these diseases usually overlap,which make the differential diagnosis difficult in clinical practice.Autonomic dysfunction is a common feature of these diseases.Recent studies indicated the autonomic dysfunction would contribute to our further understanding of centralα‑synucleinopathy.This article reviews the value of autonomic dysfunction in the predictive diagnosis,differential diagnosis and prognosis of the above diseases,to help clinical practice.