低温诱导的RBM3对各器官缺血再灌注损伤研究进展

Research progress in hypothermia-induced RBM3 in ischemia-reperfusion injury of various organs

缺血再灌注损伤(IRI)是一种复杂的血流动力学紊乱状态,致死率极高,且目前的治疗方法相对有限。亚低温治疗是临床上公认的一种缓解缺血、缺氧损伤的治疗方式,尤其在脑保护中的研究较多。多项研究表明,RNA结合基序蛋白3(RBM3)作为一种冷应激蛋白,主要在低温诱导下产生,可促进翻译,减轻氧化应激、降低细胞凋亡率。因此,诱导RBM3可能代表一种治疗IRI的新策略,代替亚低温治疗,减轻低温对机体的不良影响。基于这一观点,文章对RBM3蛋白功能的最新发现进行综述,重点关注RBM3对各器官IRI相关疾病的保护作用以及未来前景,为相关研究提供新思路。

Ischemia-reperfusion injury(IRI)is a complex hemodynamic disorder with high mortality rates and limited treatment options.Mild hypothermia is a widely-accepted treatment method for alleviating ischemic and hypoxic injury,especially in the study of brain protection.Many studies have shown that RNA-binding motif protein 3(RBM3),as a cold stress protein,is mainly produced under low-temperature induction,which can promote translation,alleviate oxidative stress,and reduce cell mortality.Therefore,inducing RBM3 may represent a new strategy for treating IRI,replacing mild hypothermia and mitigating the side effects of hypothermia on the body.In this study,the latest findings on the function of RBM3 protein were summarized,highlighting the protective role and future prospect of RBM3 in IRI-related diseases of various organs.