网膜素-1在糖尿病肾病中的保护作用机制研究进展

Research progress in the protection mechanism of omentin-1 in diabetic nephropathy

糖尿病肾病是糖尿病微血管并发症中的一种,也是终末期肾病发生的主要原因。炎症反应、氧化应激、内皮细胞和足细胞功能障碍以及代谢异常在糖尿病肾病发病过程中发挥重要作用。越来越多证据表明脂肪因子网膜素-1(omentin-1)具有多种生物学效用,可以起到肾脏保护作用。在糖尿病肾病患者中,omentin-1水平普遍减低,导致其抗炎、抗氧化应激、改善内皮以及足细胞功能、改善胰岛素抵抗等功能发生障碍,进一步加重肾病的进展。文章从omentin-1参与调节炎症、氧化应激、改善内皮细胞以及足细胞功能、改善胰岛素抵抗等方面进行综述,探讨其在糖尿病肾病中的保护作用机制,为糖尿病肾病的诊治研究提供新的思路。

Diabetic nephropathy is one of microvascular complications of diabetic nephropathy(DN)and the main cause of end-stage renal disease.Inflammation,oxidative stress,endothelial and podocyte dysfunction and metabolic abnormalities play critical roles in the pathogenesis of DN.Increasing evidence has demonstrated that omentin-1 exerts a variety of biological effects and can play a role in kidney protection.In DN patients,omentin-1 levels are generally reduced,which impairs anti-inflammation,anti-oxidative stress,endothelial cell and podocyte function and insulin resistance,and further aggravates the progression of nephropathy.In this article,the protection mechanism of omentin-1 in DN was illustrated from its role in the regulation of inflammation,oxidative stress,improvement of endothelial cell and podocyte function,and improvement of insulin resistance,aiming to provide novel ideas for the diagnosis and treatment of DN.