铁缺乏与抽动障碍关系研究进展

Research progress in the relationship between iron deficiency and tic disorder

抽动障碍是一种常见于儿童的神经发育障碍性疾病,患病率高,患者个体间临床表现差异大,常常合并其他神经精神疾病,给患者心理和生理健康带来极大的负担。抽动障碍的病因尚未明确,可能与遗传、免疫、环境及心理等多种因素有关,病理机制涉及皮质-纹状体-丘脑-皮质通路障碍及多巴胺的异常。铁在神经系统发育过程中具有重要的生物学功能。研究显示,铁缺乏可能引起大脑发育障碍、多巴胺功能受损进而导致抽动障碍的发生发展。改善机体铁营养状况、对抽动障碍患儿适当补充铁剂可能是防治抽动障碍的新思路。

Tic disorder is a common neurodevelopmental disorder disease in children,with a high prevalence and different clinical manifestations among individuals.It is frequently complicated with other neuropsychiatric diseases,which brings significant burden to psychological and physical health of patients.At present,the etiology of tic disorder remains unclear,which is probably associated with genetic,immune,environmental and psychological factors,etc.The pathological mechanism involves corticostriatum-thalamic-cortical pathway disorders and neurotransmitter abnormalities.Iron has an extremely important biological function in the developmental process of nervous system.Studies have found that iron deficiency may lead to brain development disorder and dopaminergic dysfunction,thereby causing the incidence and progression of tic disorder.Improving the nutritional status of iron through iron supplementation may become a new idea for the prevention and treatment of children with tic disorder.