同步放化疗期间头颈癌病人症状群与生活质量的相关性研究

Correlation between symptom clusters and quality of lifein patients with head and neck cancer during concurrent chemoradiotherapy

目的:调查头颈癌病人同步放化疗期间症状群及生活质量,并分析两者之间的相关性。方法:采用一般资料调查表、安德森症状评估量表-头颈部模块、头颈癌生活质量量表,对安徽省某三甲医院134例同步放化疗期间头颈癌病人进行调查。结果:通过因子分析提炼出头颈放疗特异性症状群、进食障碍症状群、病感行为症状群、心理情绪症状群、胃肠道症状群5组症状群,累积方差贡献率达72.21%,其中头颈放疗特异性症状群尤为严重;病人生活质量总分为(82.95±9.01)分,处于较低水平;5组症状群与生活质量总分均呈负相关关系(P<0.05~P<0.01);回归分析显示,除胃肠道症状群外,其余4组症状群均为生活质量的负向预测因素(P<0.05~P<0.01)。结论:头颈癌病人同步放化疗期间存在多个影响生活质量的症状群,医护人员应及时准确识别并干预,尤其是头颈放疗特异性症状群,从而提高病人的生活质量。

Objective:To investigate the status quo of symptom clusters and quality of life in patients with head and neck cancer during concurrent chemoradiotherapy,and to analyze the correlation between them.Methods:A total of 134 patients from a tertiary hospital in Anhui province were investigated with the general information questionnaire,M.D.Anderson symptom inventory-head and neck module and the functional assessment of cancer therapy-head and neck.Results:Five symptom clusters were extracted by factor analysis:head and neck radiotherapy-specific symptom cluster,eating disorder symptom cluster,sickness and behavior symptom cluster,psychological and emotional symptom cluster,and gastrointestinal symptom cluster.The cumulative variance contribution rate was 72.21%,and the head and neck radiotherapy-specific symptom cluster was the most serious.The total score of quality of life was(82.95±9.01),which was at a low level.The five symptom clusters were significantly negatively correlated with the total score of quality of life(P<0.05 to P<0.01).Regression analysis showed that except for the gastrointestinal symptom cluster,the other four symptom clusters were negative predictors of quality of life(P<0.05 to P<0.01).Conclusions:There are several symptom clusters affecting the quality of life in patients with head and neck cancer during concurrent chemoradiotherapy.Medical staff should timely and accurately identify and intervene these symptom clusters,especially the head and neck radiotherapy-specific symptom cluster,so as to improve the quality of life of patients.