NLR、PILE评分与PD-1抑制剂治疗晚期非小细胞肺癌的疗效及预后的相关性

Correlation between NLR and PILE scores and the efficacy and prognosis in advanced non-small cell lung cancer treated with PD-1 inhibitors

目的 探讨中性粒细胞-淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)、PILE评分与程序性细胞死亡蛋白-1(programmed cell death protein 1, PD-1)抑制剂治疗的晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者疗效及预后的关系。方法 回顾性分析邵阳市中心医院在2020年6月至2021年12月收治的使用PD-1抑制剂治疗的109例晚期NSCLC患者的资料,计算患者治疗前的NLR、PILE评分,分析其与疗效及预后的相关性。结果 低NLR组比高NLR组有更高的疾病控制率(disease control rate, DCR)(P<0.05),PILE评分低分组较PILE评分高分组有更高的客观缓解率(objective response rate, ORR)和DCR(均P<0.05)。在多因素分析中,NLR、PILE评分是影响PFS的独立危险因素(均P<0.05)。结论 高NLR、高PILE评分与PD-1抑制剂治疗的晚期NSCLC患者的疗效更差有关,且高NLR、高PILE评分是患者预后不良的独立危险因素。

Objective To investigate the relationship between neutrophil to lymphocyte ratio(NLR)and PILE scores and the efficacy and prognosis of patients with advanced non-small cell lung cancer(NSCLC)treated with PD-1 inhibitors.Methods The data of 109 patients with advanced NSCLC treated with PD-1 inhibitors admitted to Shaoyang Central Hospital from June 2020 to December 2021 were retrospectively analyzed.The calculate the patients pre-treatment NLR and PILE scores were calculated,and their correlation with the efficacy and prognosis were analyzed.Results The low NLR group had a higher disease control rate(DCR)than the high NLR group(P<0.05),and the low PILE score group had a higher objective response rate(ORR)and DCR than the high PILE score group(all P<0.05).In multivariate analysis,NLR and PILE scores were independent risk factors affecting patients PFS(all P<0.05).Conclusion High NLR and high PILE scores are associated with worse outcomes in patients with advanced NSCLC receiving PD-1 inhibitors and are independent risk factors for poor prognosis in patients.