摘要
牙周炎是一种常见的口腔慢性炎症,宿主因素是其致病机制之一。作为数目最多的免疫细胞,中性粒细胞可影响牙周免疫稳态,其数量或功能改变可通过多种机制加重牙周炎症,基于中性粒细胞的牙周炎干预措施在动物实验中展现出较好的牙周炎治疗前景。本文综述了中性粒细胞在牙周炎中作用的研究进展,并总结展望目前靶向中性粒细胞的治疗手段,以期为牙周炎防治提供新的视角。
Periodontitis is a prevalent and persisting oral inflammation,during which host factors are critically involved.As the most abundant immune cells,neutrophils actively partake in periodontal homeostasis,the alteration of neutrophil number or function could aggravate periodontitis through multifaceted mechanisms.Additionally,neutrophil-targeted therapies showed promising effects on treating periodontitis in animal trials.In this paper,research progress of neutrophil s role in periodontitis and immunomodulation on neutrophil were reviewed in order to provide new perspectives for periodontitis treatment.
作者
王雪奎
孙瑶
WANG Xuekui;SUN Yao(Department of Oral Implantology,Stomatological Hospital and Dental School of Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 200072,China)
出处
《口腔医学》
CAS
2024年第4期292-296,共5页
Stomatology
基金
国家自然科学基金(82270963)。
关键词
中性粒细胞
牙周炎
免疫治疗
neutrophil
periodontitis
neutrophil-modulating treatment
