炎症性肠病的肠道微生态变化及对策

Intestinal Microecological Changes and Therapeutics in Inflammatory Bowel Disease

炎症性肠病(inflammatory bowel disease,IBD)是1种慢性疾病,其特征是反复发作的肠道炎症,尽管具体原因尚未完全明确,但普遍认为它是由遗传、免疫系统异常、环境因素和肠道微生物群失衡等多重因素共同作用引起的。这些因素的相互作用可能会导致肠道环境稳态受损,进而影响宿主的免疫,最终触发肠道炎症。综述IBD患者肠道微生物群的变化情况,并探讨相应的治疗对策。

Inflammatory bowel disease(IBD)is a chronic condition characterised by recurrent inflammation of the intestines.Although the specific causes is not fully understood,it is generally believed to be caused by a combination of genetic factors,immune system abnormalities,environmental factors,and imbalances in the gut microbiota.The interaction of these factors may disrupt the intestinal environment,affecting the host's immune system,and ultimately triggering intestinal inflammation.This review discusses changes in the gut microbiota of IBD patients and explores corresponding treatment strategies.