新型冠状病毒肺炎的老年患者的凝血功能指标分析

Analysis of Coagulation Function Indexes in Elderly Patients with Novel Coronavirus Pneumonia

目的探讨凝血功能各项指标对新型冠状病毒肺炎的老年患者在诊疗中的临床意义。方法回顾性分析2022年12月至2023年1月期间,华东师范大学附属芜湖医院收治的68例新型冠状病毒感染并确诊有肺部感染的老年患者,按临床诊治方案分为普通组(n=48)与重症组(n=20),分析患者一般情况、临床表现、治疗方案、出院转归,以及D-二聚体、血浆纤维蛋白原降解产物(FDP)、血浆纤维蛋白原(Fib)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)等凝血指标的变化。结果普通组与重症组的D-二聚体与Fib均延长;重症组的D-二聚体与FDP较普通组延长且差异具有统计学意义(P<0.05);D-二聚体增高及APTT、PT延长的重症组人数占比多于普通组的人数占比(P<0.05)。结论监测老年患者凝血指标,有助于临床更好的对疾病的转归或进展进行评估。

Objective To explore the clinical significance of coagulation function indexes in the diagnosis and treatment of elderly patients with novel coronavirus pneumonia.Methods This study retrospectively analyzed 68 elderly patients with novel coronavirus infection admitted to The Wuhu Hospital,East China Normal University from December 2022 to January 2023.Patients were divided into two groups according to clinical indicators:common group(n=48)and severe group(n=20).The general condition,clinical symptoms,co-morbidity were analyzed.Coagulation index:D-dimer,plasma fibrinogen degradation products(FDP),plasma fibrinogen(Fib),prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)were measured.Results The study confirmed that D-dimer and FIB were prolonged in both the common and severe groups;Ddimer and FDP in severe group were significantly longer than those in common group(P<0.05).The proportion of patients with increased D-dimer and prolonged APTT and PT in severe group was higher than that in common group(P<0.05).Conclusion Monitoring coagulation parameters in elderly patients is helpful for clinical evaluation of the outcome or progression of the disease.