奥曲肽联合凝血酶治疗急性消化道出血的效果分析

Effect analysis of octreotide combined with thrombin in the treatment of acute gastrointestinal bleeding

目的分析急性消化道出血患者应用奥曲肽、凝血酶联合治疗的效果。方法80例急性消化道出血患者,随机分为对照组和试验组,各40例。对照组接受凝血酶治疗,试验组接受奥曲肽、凝血酶联合治疗。比较两组临床疗效、血常规指标[血红蛋白(Hb)、血小板计数(PLT)、红细胞计数(RBC)、白细胞计数(WBC)]、氧化应激指标、症状改善时间、实验室指标恢复正常时间、住院时间及不良反应发生率。结果试验组总有效率95.00%明显高于对照组的77.50%(P<0.05)。试验组治疗后Hb(115.68±12.76)g/L、PLT(146.44±14.85)×10^(9)/L、RBC(5.79±0.55)×10^(12)/L均明显高于对照组的(109.33±15.44)g/L、(134.44±14.25)×10^(9)/L、(4.85±0.42)×10^(12)/L,WBC(8.72±1.41)×10^(9)/L明显低于对照组的(9.56±1.82)×10^(9)/L(P<0.05)。试验组腹胀与腹痛改善时间(2.33±0.80)d、血氧恢复正常时间(4.24±1.01)d、血淀粉酶恢复正常时间(5.60±1.40)d、住院时间(12.60±3.11)d均明显短于对照组的(3.49±1.15)、(5.33±1.61)、(7.20±1.84)、(17.69±4.80)d(P<0.05)。与对照组相比,试验组治疗后超氧化物歧化酶、谷胱甘肽过氧化物酶水平均明显较高,脂质过氧化氢、丙二醛水平均明显较低(P<0.05)。两组不良反应发生率比较无差异(P>0.05)。结论对急性消化道出血患者施以奥曲肽、凝血酶联合治疗效果良好,不但可保证治疗效果和安全性,同时可优化血常规指标和氧化应激指标,还可缩短治疗时间值得推广。

Objective To analyze the effect of octreotide combined with thrombin in the treatment of acute gastrointestinal bleeding.Methods 80 patients with acute gastrointestinal bleeding were randomly divided into a control group and an experimental group,with 40 cases in each group.The control group received thrombin treatment,and the experimental group received octreotide and thrombin combined treatment.Both groups were compared in terms of clinical efficacy,blood routine indicators[hemoglobin(Hb),platelet count(PLT),red blood cell count(RBC),white blood cell count(WBC)],oxidative stress indexes,symptom improvement time,recovery time of laboratory indicators,hospital stay and incidence of adverse reactions.Results The total effective rate of 95.00%in the experimental group was significantly higher than 77.50%in the control group(P<0.05).After treatment,the experimental group had Hb of(115.68±12.76)g/L,PLT of(146.44±14.85)×10^(9)/L,RBC of(5.79±0.55)×10^(12)/L,which were significantly higher than(109.33±15.44)g/L,(134.44±14.25)×10^(9)/L,(4.85±0.42)×10^(12)/L in the control group;the experimental group had significantly lower WBC of(8.72±1.41)×10^(9)/L than(9.56±1.82)×10^(9)/L in the control group(P<0.05).In the experimental group,the improvement time of abdominal distension and abdominal pain was(2.33±0.80)d,the recovery time of blood oxygen was(4.24±1.01)d,the recovery time of blood amylase was(5.60±1.40)d,and the hospital stay was(12.60±3.11)d,which were significantly shorter than(3.49±1.15),(5.33±1.61),(7.20±1.84),and(17.69±4.80)d in the control group(P<0.05).Compared with the control group,the levels of superoxide dismutase and glutathione peroxidase in the experimental groups after treatment were significantly higher,and the levels of lipid hydrogen peroxide and malondialdehyde were significantly lower(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of octreotide and thrombin in patients with acute gastrointestinal bleeding is effective,which not only ensures the therapeutic effect and safety,but also optimizes the blood routine indicators and oxidative stress indicators,and shortens the treatment time,which is worth promoting.