某三甲妇幼保健院413例药品不良反应回顾性分析

Retrospective analysis of 413 cases of adverse drug reactions in a grade-A maternal and child health hospital

目的分析枣庄市妇幼保健院药品不良反应(ADR)发生的特点和规律,查找发生的原因并提出相应的对策,旨在促进临床安全合理用药。方法对枣庄市妇幼保健院2022年上报国家药品不良反应监测系统的413例报告进行回顾性分析。结果413例ADR报告中0~17岁年龄段发生率最高;其中一般ADR 261例,严重ADR 85例,新的ADR 67例。ADR发生率前3位药品种类为抗感染药物(37.29%),妇产科用药(25.67%),抗肿瘤药(15.25%);发生率前3位药品品种为注射用阿奇霉素(10.41%)、注射用紫杉醇(白蛋白结合型)(8.47%)、注射用头孢曲松钠(7.75%)。以皮肤及其附件损害和胃肠系统损害为主,大多发生在120 min以后。结论临床应加强特殊人群用药ADR科普教育,早发现、早治疗,提高安全合理用药水平。

Objective To analyze the characteristics and rules of adverse drug reactions(ADR)in Zaozhuang Maternal and Child Health Hospital,find out the causes and put forward the corresponding countermeasures,in order to promote clinical safety and rational drug use.Methods A retrospective analysis was made on 413 cases reported to the National Adverse Drug Reaction Monitoring System by Zaozhuang Maternal and Child Health Hospital in 2022.Results Among the 413 ADR reports,the highest incidence was in the age group of 0-17 years.There were 261 cases of general ADR,85 cases of severe ADR and 67 cases of new ADR.Among the 413 ADR reports,the highest incidence was in the age group of 0-17 years.There were 261 cases of general ADR,85 cases of severe ADR and 67 cases of new ADR.The top 3 types of ADR were anti-infective drugs(37.29%),obstetrics and gynecology drugs(25.67%)and anti-tumor drugs(15.25%).The top 3 drug varieties were azithromycin for injection(10.41%),paclitaxel for injection(albumin-bound)(8.47%)and ceftriaxone sodium for injection(7.75%).Damage to the skin and its accessories and damage to the gastrointestinal system were predominant,mostly occurring after 120 min.Conclusion Clinical education of ADR for special population should be strengthened,early detection and treatment should be carried out to improve the level of safe and rational drug use.