脐灸联合参芪利水颗粒治疗慢性阻塞性肺疾病急性加重期(阳虚水泛证)临床观察

Clinical Observation of Umbilical Cord Moxibustion Combined with Shenqi Lishui Granules in the Treatment of Acute Exacerbations Chronic Obstructive Pulmonary Disease with Syndrome of Water Overflowing due to Yang Deficiency

目的观察脐灸联合参芪利水颗粒治疗慢性阻塞性肺疾病急性加重期(阳虚水泛证)临床疗效。方法选择患者60例随机分为对照组与观察组各30例。对照组给予西医常规治疗,观察组在对照组治疗基础上予脐灸联合参芪利水颗粒治疗,治疗2周后,观察比较两组改良版英国医学研究委员会呼吸问卷(mMRC)评分、慢性阻塞性肺疾病评分(CAT)、血气分析指标及血清炎性因子[免疫血清降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、临床疗效及治疗安全性。结果两组治疗后mMRC评分,CAT评分,动脉血二氧化碳分压(PaCO_(2))水平,血清PCT、TNF-α、IL-6水平均降低(均P<0.05),且观察组各项量表评分和实验室指标水平均低于对照组(均P<0.05);两组治疗后动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))指标水平明显升高(均P<0.05),且观察组均高于对照组(均P<0.05);观察组总有效率为93.33%,明显高于对照组的66.67%(P<0.05)。两组治疗期间均未见与治疗药物相关的不良反应。结论脐灸联合参芪利水颗粒可抑制慢性阻塞性肺疾病急性加重期(阳虚水泛证)炎性反应,改善患者血气分析指标,缓解呼吸困难,疗效明显。

Objective:To investigate the clinical efficacy of umbilical cord moxibustion combined with Shenqi Lishui granules in the treatment of acute exacerbations of chronic obstructive pulmonary disease(AECOPD)with syndrome of water overflowing due to yang deficiency.Methods:A total of 60 patients with AECOPD were randomly divided into control group and observation group,with 30 cases in each group.After 2 weeks of treatment,the modified Medical Research Council(mMRC)score,COPD Assessment Test(CAT)score,blood gas analysis indexes,serum inflammatory factors[immune serum procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels,clinical efficacy and treatment safety were observed and compared.Results:After treatment,the mMRC score,CAT score,PaCO_(2) level,serum PCT,TNF-αand IL-6 levels decreased in the two groups(all P<0.05),and the scores of various scales and laboratory indicators in the observation group were lower than those in the control group(all P<0.05).The level of SaO_(2) index was significantly higher(all P<0.05),and the observation group was higher than that of the control group(all P<0.05),and the total effective rate of the observation group(93.33%)was significantly higher than that of the control group(66.67%)(P<0.05).No adverse reactions related to the treatment were observed in either group.Conclusion:Umbilical moxibustion combined with Shenqi Lishui granules can inhibit the inflammatory response in AECOPD with syndrome of water overflowing due to yang deficiency,improve the blood gas analysis indexes of patients,and alleviate dyspnea,with obvious efficacy.