多中心性网状组织细胞增生症1例并文献复习

Multicentric Reticulohistiocytosis a Case Report and Literature Review

报告1例多中心性网状组织细胞增生症,并进行文献复习,旨在为今后的临床诊治提供指导。患者女,43岁,因双手甲皱、前胸及耳郭多发暗红色结节4年,双手关节炎病史5年,全身系统检查未见淋巴结肿大和内脏占位。辅助检查:双手X线片:远节指间关节面下骨质欠光整,关节面骨质硬化。组织病理检查:真皮内组织细胞数目增多,并见多核巨细胞,细胞膜清楚,内含均匀细颗粒状物质,呈“毛玻璃”状,PAS(+)。免疫组化:组织细胞CD68阳性,S-100和CD1a阴性。诊断:多中心性网状组织细胞增生症。

A case of multicentric reticular histiocytosis is reported,along with a literature review aimed at providing guidance for future clinical diagnosis and treatment.A 43-year-old woman patient who presented with multiple dark red nodules in the nail folds of both hands,the anterior chest and the auricles for 4 years,a history of arthritis in both hands for 5 years,and no enlarged lymph nodes or visceral occupations on systemic examination.Ancillary examination:X-ray film of both hands:the bone under the articular surface of the distal interphalangeal joint was not smooth,and the articular surface was sclerotic.Histopathological examination:granulomatous proliferation of histiocytes was seen in the dermis,and multinucleated giant cells were seen,with clear cell membranes,obvious nuclei,rich cytoplasm and uniform fine granular material,which was in the form of"hairy glass".Immunohistochemistry:CD68(+),S-100(-),CD1a(-).Diagnosis:multicentric reticulohistiocytosis.