腹腔镜左肝切除术治疗左肝内胆管结石的临床疗效研究

Clinical efficacy of laparoscopic left hepatectomy for left intrahepatic bile duct stones

目的比较开腹和腹腔镜左肝切除术治疗左肝内胆管结石的临床疗效。方法回顾性收集2016年1月1日至2022年1月1日在宁波市鄞州区第二医院普外科收治的136例行肝切除术治疗患者的临床资料,纳入接受左肝切除术治疗者132例,使用倾向性评分匹配法对开腹肝左叶切除(open left-sided hepatectomy,OLH)组和腹腔镜肝左叶切除(laparoscopic left-sided hepatectomy,LLH)组患者进行1∶1匹配,两组各47例。主要观察指标:手术时间、术中出血量、术中输血率、术后住院时间、并发症发生率、胆瘘发生率、结石清除率及结石复发率等。结果与OLH组比较,LLH组术后住院时间短、术后并发症发生率低、术后胆瘘发生率低,差异有统计学意义(P<0.05)。两组初步结石清除率、最终结石清除率、结石复发率差异无统计学意义(P>0.05)。多因素分析结果显示,开腹手术和术后并发症是延长术后住院时间的独立危险因素开腹手术是术后胆瘘的独立危险因素左肝外叶切除、术后胆瘘和合并多处结石是结石复发的独立危险因素。结论腹腔镜左肝切除术治疗左肝内胆管结石是安全有效的,术后胆瘘以及合并多处结石是肝内胆管结石术后复发的独立危险因素。

Objective To compare the clinical efficacy of open and laparoscopic left hepatectomy for the treatment of left intrahepatic bile duct stones.Methods The clinical data of 136 patients treated with hepatectomy admitted to the Department of General Surgery of the Second Hospital of Yinzhou District,Ningbo from January 1,2016 to January 1,2022 were retrospectively collected.132 patients treated with left hepatectomy were included,and the propensity score matching method was used to perform 1∶1 matching between the open left lobe hepatectomy(OLH)and laparoscopic left lobe hepatectomy(LLH)groups.Forty-seven patients were matched in each group.The main observations were:operative time,intraoperative bleeding,intraoperative blood transfusion rate,postoperative hospital stay,complication rate,biliary fistula rate,stone removal rate and stone recurrence rate.Results The LLH group had a shorter postoperative hospital stay,a lower postoperative complication rate and a lower postoperative biliary fistula rate(P<0.05).There was no statistically significant difference in the initial stone removal rate,final stone removal rate and stone recurrence rate between the two groups.Multifactorial analysis showed that open surgery and postoperative complications were independent risk factors for prolonge postoperative hospital stay.Open surgery was an independent risk factor for postoperative biliary fistula;left extrahepatic lobectomy,postoperative biliary fistula and combined multiple stones were independent risk factors for stone independent risk factors for recurrence.Conclusion Laparoscopic left hepatectomy for left intrahepatic bile duct stones is safe and effective.Postoperative biliary fistula and the combination of multiple stones were independent risk factors for recurrence of intrahepatic bile duct stones after surgery.