血清癌胚抗原相关细胞黏附分子1 脂质运载蛋白-2 恶性肿瘤特异生长因子联合检测鉴别诊断乳腺癌的价值

Value of combined detection of serum carcinoembryonic antigen associated cell adhesion molecule 1,lipid carrier protein 2 and malignant tumor specific growth factor in differential diagnosis of breast cancer

目的 探讨血清癌胚抗原相关细胞黏附分子1(CEACAM1)、脂质运载蛋白2(LCN-2)、恶性肿瘤特异生长因子(TSGF)联合检测鉴别诊断乳腺癌的价值。方法 本研究为回顾性分析,对我院2021年1月至2023年1月收治的40例良性乳腺肿瘤患者临床资料进行收集,作为对照组;并对同期医院收治的40例乳腺癌患者临床资料进行收集,作为观察组。设计基线资料填写表,详细对2组基线资料、血清检查指标进行填写、比较,重点分析血清CEACAM1、LCN-2、TSGF联合检测鉴别诊断乳腺癌的价值。结果 观察组血清CEACAM1、LCN-2、TSGF水平比对照组高,差异有统计学意义(P<0.05),组间年龄、体质指数(BMI)、肿瘤直径、绝经及患侧比较,差异无统计学意义(P>0.05);绘制受试者工作曲线(ROC)结果显示,血清CEACAM1、LCN-2、TSGF检测鉴别诊断乳腺癌的曲线下面积(AUC)均>0.70,且以联合检测(并联)价值最佳。结论 血清CEACAM1、LCN-2、TSGF联合检测鉴别诊断乳腺癌有较高的灵敏度、特异度,鉴别诊断价值满意。

Objective To investigate the value of serum carcinoembryonic antigen associated cell adhesion molecule 1(CEACAM1),lipid carrier protein 2(LCN-2)and malignant tumor specific growth factor(TSGF)in the differential diagnosis of breast tumors.Methods Clinical data of 4O patients with benign breast tumor admitted to our hospital from January 2021 to January 2023 were collected as control group,and clinical data of 40 patients with breast cancer admitted to our hospital during the same period were collected as observation group.The baseline data filling table was designed to fill in and compare the baseline data and serum examination indicators of the two groups in detail,and the value of the combined detection of serum CEACAM1,LCN-2 and TSGF in differentiating the nature of breast tumors was analyzed.Results The levels of CEACAM1,LCN-2 and TSGF in the observation group were higher than those in the control group,with statistical differences(P<0.05),but there were no statistical differences in age,body mass index(BMI),tumor diameter,menopause and the affected side(P>0.05).Receiver operating curve(ROC)results showed that the area under the curve(AUC)of serum CEACAM1,LCN-2 and TSGF in differential diagnosis of breast cancer were all greater than O0.70,and the value of combined detection(parallel)was the best.Conclusion The combined detection of serum CEACAM1,LCN-2 and TSGF has high sensitivity and specificity in the differential diagnosis of breast tumor,and the differential diagnosis value is satisfactory.