原发性干燥综合征并发感染病原菌与危险因素

Investigation of pathogenic bacteria distribution and risk factors in patients with primary Sjogren's syndrome complicate with infection

目的探究原发性干燥综合征并发感染患者的病原菌种类分布、临床特征及易感因素。方法回顾性分析2021年1月-2023年2月安庆市立医院收治的118例原发性干燥综合征患者的临床资料,根据患者是否发生感染分为感染组(n=32例)和未感染组(n=86例)。收集原发性干燥综合征患者的临床资料并统计并发感染发生率及感染部位分布,统计感染病原菌种类分布,采用Logistic回归分析法分析原发性干燥综合征患者并发感染的易感因素。结果118例原发性干燥综合征患者并发感染32例,发生率为27.12%,其中呼吸道感染占比最多;病原菌为33株,以革兰阴性菌(39.39%)中的大肠埃希菌、革兰阳性菌(27.27%)中的金黄色葡萄球菌为主;年龄大、总蛋白低、白蛋白低是原发性干燥综合征患者并发感染的易感因素(P<0.05)。结论原发性干燥综合征患者并发感染发生率较高,且主要为呼吸道感染,病原菌主要为大肠埃希菌和金黄色葡萄球菌,其易感因素为年龄大、总蛋白低、白蛋白低。

OBJECTIVE To explore the pathogenic bacteria distribution,clinical features and predisposing factors in patients with primary Sjogren's syndrome complicate with infection.METHODS The clinical data of 118 patients with primary Sjogren's syndrome admitted to Anqing Municipal Hospital from Jan 2021 to Feb 2023 were retro-spectively recruited in the study.According to whether the infection occurred in patients,they were divided into the infection group(n=32 cases)and non-infection group(n=86 cases).The clinical data of patients with prima-ry Sjogren's syndrome were collected,and the incidence of infection,the distribution of infection sites and the pathogenic distribution were ananlyzed.Multivariate logistic regression analysis was used to analyze the susceptible factors of infection in patients with primary Sjogren's syndrome.RESULTS Among 118 patients with primary Sjogren's syndrome,32 cases were complicated with infection,with an incidence of 27.12%,of which respiratory tract infection accounted for the largest proportion,33 strains of pathogenic bacteria,mainly Escherichia coli among gram-negative(39.39%)and Staphylococcus aureus among gram-positive bacteria(27.27%).Aged,low total protein,low albumin were predisposing factors for co-infection in patients with primary Sjogren's syndrome(P<0.05).CONCLUSION The incidence of co-infection in patients with primary Sjogren's syndrome was high,and the main infection site was respiratory tract,and the main pathogens were E.coli and S.aureus.The suscepti-bility factors were aged,low total protein and low albumin.