血清IL-6和IL-8水平对肺癌术后感染的预测价值

Value of IL-6 and IL-8 levels in prediction of postoperative infection in lung cancer patients

目的探究行胸腔镜肺癌根治术的肺癌患者血清白细胞介素(IL)-6和IL-8水平预测术后感染中的作用。方法选取淄博市第一医院2020年1月-2022年12月接受了胸腔镜肺癌根治手术的136例肺癌患者,所有患者按照手术后7d内是否出现医院感染分为感染组和未感染组,比较两组患者的基本资料、手术前后血清IL-6和IL-8水平,分析影响患者术后感染的危险因素,分析IL-6和IL-8评估术后感染的效能。结果共21例患者出现感染症状,感染率15.44%;感染组出现感染症状的患者年龄均偏大、手术时间更长,感染组患者术后(1、3d)血清IL-6和IL-8水平均高于未感染组(P<0.05);年龄、手术时间是影响患者术后感染的危险因素(P<0.05);受试者工作特征(ROC)曲线分析结果显示,IL-6、IL-8及两者联合曲线下面积分别为0.712、0.682和0.795,均具有统计学差异(P<0.05)。结论行胸腔镜肺癌根治术的肺癌患者年龄和手术时间是发生医院感染的因素,IL-6和IL-8联合检测对术后感染具有更高的预测价值,应重点关注。

OBJECTIVE To explore the role of serum interleukin(IL)-6 and IL-8 levels in predicting postoperative infection in lung cancer patients undergoing thoracoscopy radical resection.METHODS A total of 136 lung cancer patients who underwent thoracoscopy radical resection surgery in Zibo First People's Hospital from Jan 2020 to Dec 2022 were recruited.All the patients were divided into the infection group and the uninfected group according to whether nosocomial infection occurred within seven days after surgery.The basic data of the two groups of pa-tients,the levels of serum IL-6 and IL-8 before and after surgery were compared;the independent risk factors af-fecting patients'postoperative infection were analyzed,and the efficacy of IL-6 and IL-8 levels in evaluating post-operative infection was analyzed.RESULTS A total of 21 patients showed symptoms of infection,with a probabili-ty of infection of 15.44%.Patients with infection symptoms in the infection group were older and had longer surgi-cal times.The levels of serum IL-6 and IL-8 of the infected group were higher than those of the uninfected group after surgery for(1 day,3 days)(P<0.05).Age and surgical time were risk factors for postoperative infection(P<0.05).The ROC analysis showed that values of areas under the curves of IL-6,IL-8 and their combination were 0.712,0.682,and 0.795,respectively,with statistical significance(P<0.05).CONCLUSION Age and oper-ation time in lung cancer patients undergoing thoracoscopic radical lung cancer surgery are risk factors for the nos-ocomial infection,and the combined detection of IL-6 and IL-8 levels has a higher predictive value for postopera-tive infection.Clinic should pay more attention.