微小RNA在肾组织纤维化中作用的研究进展

Progress in role of microRNA in renal fibrosis

糖尿病、高血压、肾小球肾炎以及其它肾脏疾病常常发展为慢性肾病(chronic kidney disease,CKD)。预计到2030年,慢性肾病引发肾脏功能衰竭和心脏并发症将成为全球第13大死因,而到2040年将上升到第5位死因[1]。CKD的组织病理学特点,一个是持续性肾组织炎症反应,另一个是以过多细胞外基质沉积为特征的肾小管间质和肾小球纤维化[2]。

Progressive renal fibrosis is the hallmark of chronic kidney disease,which possesses heavy public health burden globally.Both diabetic and non-diabetic kidney diseases are the major causes for development of chronic kidney disease.MicroRNAs(miRNAs),short noncoding RNAs,exert their regulatory roles at a post-transcription level and have been studied for renal fibrosis progression in diabetic and non-diabetic nephropathy.In this review,the pattern of miRNA expression alternations in diabetic and non-diabetic kidney diseases is summarized followed by discussion on the roles of miRNAs in renal fibrosis through interacting with various signaling pathways,such as transforming growth factor-β,nuclear factor-κB,Janus kinase/signal transducer and activator of transcription,tissue inhibitor of metalloproteinase 3,and SRY-box transcription factor 6.The potential of physical exercise in protection of renal dysfunction by regulating miRNAs is briefly discussed.