基于全国抗菌药物临床应用监测网的手术组病例用药合理性分析

Analysis of the Rationality of Drug Use in the Surgical Group Based on the Center for Antibacterial Surveillance

目的分析全国抗菌药物临床应用监测网中手术组病例用药的合理性。方法通过建立抗菌药物临床应用监测网病例评价标准,对手术组病例抗菌药物使用的合理性进行评价。结果我国手术组病例预防用抗菌药物使用率呈下降趋势,2021年Ⅰ类切口手术预防用抗菌药物的使用率为32.20%,无适应证用药的比例从2017年的11.35%下降到2021年的6.87%,抗菌药物预防使用的合理率从2017年的15.05%上升到2021年的29.73%。不合理用药情况主要表现为围手术期用药不合理,构成比5年均值为55.13%;其次为药物选择不合理,构成比5年均值为18.58%;以及每日给药次数、单次剂量不合理等。结论需持续加强手术抗菌药物使用管理和监测力度,保障临床用药安全。

Objective To analyze the rationality of clinical application of antibiotics in the surgical group based on the Center for Antibacterial Surveillance in China.Methods The reasonableness of the use of antibiotics in the surgical group was evaluated by establishing the case evaluation criteria of the Center for Antibacterial Surveillance.Results The use of preventive antibiotics in the surgical group showed a decreasing trend.In 2021,the use of preventive antibiotics in Class I incision surgery was 32.20%,and the rate of use without indication decreased from 11.35%in 2017 to 6.87%in 2021.The Rationalization rate of antibiotics use increased from 15.05%in 2017 to 29.73%in 2021.Irrational use of drugs was mainly due to Irrational drugs use in the perioperative period,with an average composition ratio of 55.13%in 5 years,followed by irrational medications selection,with an average composition ratio of 18.58%in 5 years,and unreasonable daily administration times and single dose.Conclusion It is necessary to strengthen the management and monitoring of antibiotics use in surgery to ensure the safety of clinical use.