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New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp.ZS03

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摘要 A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designated arthrinoids A–G (1–7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL^(−1).
机构地区 Department of Pharmacy
出处 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2024年第4期356-364,共9页 中国天然药物(英文版)
基金 supported by the National Natural Science Foundation of China(No.82003956) the Henan Young Elite Scientists Sponsorship Program(No.2023HYTP032)。
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