摘要
骨组织中细胞的结构和功能异质性与其空间位置密切相关。空间转录组(spatial transcriptomics)技术能够同时获得组织内空间单元的位置信息和转录组变化。近年来,空间转录组技术的迅速发展使组织器官的高分辨率和高通量转录组分析得以实现,并不断应用于骨骼系统的研究中。本文就空间转录组技术的进展及其在骨研究中的应用作一综述。
The structural and functional heterogeneity of cells in bone tissue is closely related to their spatial location.Spatial transcriptomics can simultaneously obtain location information and transcriptome changes of spatial units within tissues.In recent years,the rapid development of spatial transcriptomics has enabled high-resolution and high-throughput transcriptome analysis of tissues and organs,and has been continuously applied in the study of the skeletal system.This article reviews the progress of spatial transcriptomics and its applications in bone research.
作者
陈永亮
王佐林
CHEN Yongliang;WANG Zuolin(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Oral Implantology,Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)
出处
《口腔颌面外科杂志》
CAS
2024年第2期143-145,共3页
Journal of Oral and Maxillofacial Surgery
基金
科技部重点研发专项(2018YFE0202200)
国家自然科学基金(81670962)
同济大学中央高校基本业务费专项资金(22120180196)。
关键词
空间转录组
下一代测序
骨髓微环境
间充质干细胞
spatial transcriptomics
next generation sequencing
bone marrow microenvironment
mesenchymal stem cell
