地塞米松联合盐酸氨溴索鼓室注射治疗分泌性中耳炎的临床效果

Clinical Effect of Dexamethasone Combined with Ambroxol Hydrochloride Tympanic Injection in Treatment of Secretory Otitis Media

目的:探讨地塞米松联合盐酸氨溴索鼓室注射治疗分泌性中耳炎的临床效果。方法:选取2020年1月—2022年12月于丽水市莲都区人民医院治疗的分泌性中耳炎患者70例为研究对象,随机分为对照组和观察组,各35例。对照组采用地塞米松注射液鼓室注射治疗,观察组采用地塞米松联合盐酸氨溴索鼓室注射治疗。比较两组炎性因子、免疫指标、听力功能、临床疗效。结果:治疗后,两组白细胞介素-8、白细胞介素-1β、肿瘤坏死因子-α水平降低,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)水平升高,CD8^(+)水平降低,观察组CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组中耳压力、耳道容积、骨导听阈值降低,观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组,差异有统计学意义(P=0.029)。结论:地塞米松注射液联合盐酸氨溴索鼓室注射可促进分泌性中耳炎患者炎性反应、免疫功能的改善,促进患耳恢复,提高听力功能。

Objective:To investigate the clinical effect of dexamethasone combined with ambroxol hydrochloride tympanic injection in the treatment of secretory otitis media.Methods:Seventy patients with secretory otitis media treated in Lishui City Liandu District People's Hospital from January 2020 to December 2022 were selected as the study objects,randomly divided into control group and observation group,35 cases in each group.The control group was treated by tympanic injection of dexamethasone injection,and the observation group was treated by tympanic injection of dexamethasone combined with ambroxol hydrochloride.The inflammatory factors,immune indexes,hearing function and clinical efficacy of the two groups were compared.Results:After treatment,the levels of interleukin-8,interleukin-1βand tumor necrosis factor-αin two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);after treatment,the levels of CD4+and CD4+/CD8+increased and CD8+decreased in both groups,and the levels of CD4+and CD4+/CD8+in the observation group were higher than those in the control group,while the levels of CD8+were lower than those in the control group,with statistical significance(P<0.05);after treatment,the middle ear pressure,ear canal volume and bone conduction threshold of two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.029).Conclusion:Dexamethasone injection combined with ambroxol hydrochloride tympanic injection can promote the improvement of inflammatory response,immune function,ear recovery and hearing function in patients with secretory otitis media.