黄芪桂枝五物汤联合加巴喷丁治疗尿毒症不宁腿综合征患者的效果

Effect of Huangqi Guizhi Wuwu Decoction Combined with Gabapentin in the Treatment of Patients with Uremic Restless Legs Syndrome

目的:探讨黄芪桂枝五物汤联合加巴喷丁治疗尿毒症不宁腿综合征(RLS)的效果。方法:选取2022年6月—2023年6月湖南中医药大学第一附属医院肾脏内科尿毒症RLS患者60例为研究对象,随机分为对照组和观察组,各30例。对照组使用加巴喷丁治疗,观察组在对照组基础上加用黄芪桂枝五物汤治疗。比较两组临床疗效、睡眠质量、症状指标及情绪状态。结果:观察组总有效率高于对照组,差异有统计学意义(P=0.006);治疗后,两组睡眠质量、睡眠效率、入睡时间、睡眠时间、睡眠障碍、催眠药物、日间功能障碍评分均降低,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组国际下肢不宁腿综合征等级评估量表、汉密尔顿焦虑量表、汉密尔顿抑郁量表评分降低,观察组低于对照组,差异有统计学意义(P<0.05)。结论:黄芪桂枝五物汤联合加巴喷丁治疗尿毒症RLS的效果确切,能有效缓解症状,改善睡眠及心理状况。

Objective:To explore the effect of Huangqi Guizhi Wuwu decoction combined with gabapentin in the treatment of ure⁃mic restless legs syndrome(RLS).Methods:Sixty uremic RLS patients in the Department of Nephrology,the First Affiliated Hospi⁃tal of Hunan University of Traditional Chinese Medicine from June 2022 to June 2023 were selected as the research subjects and randomly divided into a control group and an observation group,with 30 cases in each.The control group was treated with gabapen⁃tin,and the observation group was additionally treated with Huangqi Guizhi Wuwu decoction on the basis of the control group.The clinical efficacy,sleep quality,symptom indicators and emotional state of the two groups were compared.Results:The total effec⁃tive rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.006);after treatment,the sleep quality,sleep efficiency,fall-asleep time,sleep time,sleep disorder,hypnotic drugs,and daytime dysfunc⁃tion scores of both groups were reduced,the observation group was lower than the control group,and the difference was statisti⁃cally significant(P<0.05);after treatment,the scores of the International Restless Legs Syndrome Rating Scale,Hamilton Anxiety Rating Scale,and Hamilton Depression Rating Scale were reduced in both groups;the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:Huangqi Guizhi Wuwu decoction combined with gabap⁃entin is effective in treating uremic RLS,and can effectively relieve symptoms and improve sleep and psychological conditions.