炎症性肠病患者微量元素锌、硒缺乏患病率的Meta分析

Prevalence of zinc and selenium deficiency in patients with inflammatory bowel disease:a Meta-analysis

目的系统评价炎症性肠病(inflammatory bowel disease,IBD)患者微量元素锌、硒缺乏患病率。方法计算机检索知网、万方、维普、PubMed、EmBase及Cochrane Library数据库,搜集包含IBD患者微量元素锌、硒缺乏患病率的临床研究,检索时限均从建库至2022年11月9日。两名评审员通过阅读全文独立地筛选需要纳入的文献,提取资料并评价纳入研究的偏倚风险后,采用Stata 15.1软件进行Meta分析。结果共纳入14项研究,包括2915例IBD患者。Meta分析结果显示,IBD患者锌缺乏总患病率为29%(95%CI:21%~37%),硒缺乏总患病率为10%(95%CI:7%~14%)。根据疾病类型进行亚组分析结果显示:溃疡性结肠炎(ulcerative colitis,UC)患者锌缺乏患病率为23%(95%CI:13%~34%),硒缺乏患病率为7%(95%CI:4%~10%);克罗恩病(Crohn′s disease,CD)患者锌缺乏患病率为34%(95%CI:23%~45%),硒缺乏患病率为14%(95%CI:10%~18%)。结论IBD患者微量元素锌、硒缺乏总患病率较高,且CD患者锌、硒缺乏患病率均高于UC患者。

Objective To systematically review the prevalence of zinc and selenium deficiency in patients with inflammatory bowel disease(IBD).Methods The CNKI,WanFang Data,VIP,PubMed,EmBase and The Cochrane Library databases were electronically searched to collect studies on the prevalence of zinc and selenium deficiency in patients with IBD from inception to Nov.9th,2022.Two reviewers independently screened the literature by reading the full text,extracted data and assessed the risk of bias of the included studies.Meta-analysis was then performed using Stata 15.1 software.Results A total of 14 studies involving 2915 IBD patients were included.The Meta-analysis results showed that the prevalence of zinc deficiency was 29%(95%CI:21%-37%),and the prevalence of selenium deficiency was 10%(95%CI:7%-14%)in IBD patients.Subgroup analysis according to disease types showed that the prevalence of zinc deficiency was 23%(95%CI:13%-34%),and the prevalence of selenium deficiency was 7%(95%CI:4%-10%)in patients with ulcerative colitis(UC).The prevalence of zinc deficiency was 34%(95%CI:23%-45%).and the prevalence of selenium deficiency in patients with CD was 14%(95%CI:10%-18%)in patients with Crohn′s disease(CD).Conclusion The total prevalence of zinc and selenium deficiency in IBD patients is high,and the prevalence of zinc and selenium deficiency in CD patients is higher than that in UC patients.