Wnt信号通路参与周围神经病理性疼痛的研究进展

Research progress on the mechanism of Wnt signaling pathway in peripheral neuropathic pain

神经病理性疼痛是由躯体感觉系统的损伤或疾病引起的疼痛综合征,临床上周围神经病理性疼痛(pNP)较为常见,主要表现为自发痛、痛觉超敏、痛觉过敏和感觉异常等,其发病机制较为复杂且存在争议。目前临床治疗以药物为主,效果欠佳且不良反应较多。Wnt信号通路在神经发育中对细胞增殖分化起重要作用,可通过调控神经损伤修复参与pNP的发生。本文就Wnt信号通路与pNP的联系进行综述,旨在为寻找更为安全有效的治疗靶点提供指导依据。

Neuropathic pain is the pain syndrome caused by damage or disease of the somatosensory system,clinically,the common type is peripheral neuropathic pain(pNP),mainly manifested as spontaneous pain,allodynia,hyperalgesia and paresthesia,with complex and controversial pathogenesis.At present,clinical treatment is mainly based on drugs,with poor effect and more adverse events.Wingless-type MMTV integration site family(Wnt) signaling pathway plays an important role in cell proliferation and differentiation in neurodevelopment and can participate in the occurrence of pNP by regulating nerve injury repair.This article reviews the relationship between Wnt signaling pathway and pNP,in order to provide guidance for more safe and effective therapeutic targets.