细胞焦亡在脓毒症急性肺损伤中作用的研究进展

Research progress of pyroptosis and its effect in sepsis-induced acute lung injury

脓毒症是严重感染和创伤的常见并发症,为导致急性肺损伤的常见病因之一。脓毒症急性肺损伤是一种以低氧血症和通气困难为特征的临床综合征,可进展为急性呼吸窘迫综合征。脓毒症急性肺损伤的发病机制目前尚未明确,缺乏有效的靶向治疗措施。细胞焦亡是以细胞膜穿孔和炎性因子释放为特征的程序性细胞死亡。细胞焦亡在脓毒症急性肺损伤发生发展中具有重要作用,为潜在的治疗靶点。本文主要对细胞焦亡的分子机制以及不同类型细胞焦亡参与脓毒症急性肺损伤的机制进行综述,以期为制定新的脓毒症急性肺损伤治疗策略提供理论依据。

Sepsis is a common complication of combat trauma and injuries,and is one of the common causes of acute lung injury.Sepsis-induced acute lung injury is a clinical syndrome characterized by hypoxemia and dyspnea,which can progress to acute respiratory distress syndrome.The pathogenesis of sepsis-induced acute lung injury is not fully understood,and there is still no effective targeted intervention.Pyroptosis is a form of programmed cell death characterized by membrane perforation and inflammatory factor releasing.In recent years,studies have found that pyroptosis plays an important role in the occurrence and development of sepsis-induced acute lung injury and is a potential therapeutic target.In this article,the molecular mechanism of pyroptosis and the mechanism of pyroptosis of different types of cells involved in sepsis-induced acute lung injury are summarized,in order to provide theoretical basis for new treatment strategies for sepsis-induced acute lung injury.