自体富血小板血浆联合点阵激光及非那雄胺治疗雄激素性脱发的临床研究

Clinical study of autologous platelet-rich plasma combined with fractional laser and finasteride in the treatment of androgenetic alopecia

目的研究自体富血小板血浆(PRP)联合点阵激光及非那雄胺治疗雄激素性脱发(AGA)的效果。方法选取天津市北辰医院2022年5月~2023年5月收治的AGA患者80例,依照治疗方案差异分为3组,A组(26例)接受非那雄胺治疗,B组(26例)接受点阵激光及非那雄胺治疗,C组(28例)接受自体PRP、点阵激光、非那雄胺联合治疗。比较三组临床疗效、治疗前及治疗后3个月主观症状(油腻、脱发、瘙痒、鳞屑)评分、毛发镜检结果(平均毛干直径、平均毳毛比、平均毛发密度)。结果C组临床总有效率高于B组和A组(P<0.05)。治疗后3个月,C组油腻、脱发、瘙痒、鳞屑评分<B组<A组(P<0.05)。治疗后3个月,三组平均毛干直径、平均毳毛比、平均毛发密度均得到改善,且C组平均毛干直径、平均毛发密度>B组、A组,而平均毳毛比<B组、A组(P<0.05)。结论自体PRP、点阵激光、非那雄胺联合治疗AGA的效果显著,能有效改善患者临床症状。

Objective To study the efficacy of autologous platelet-rich plasma(PRP)combined with fractional laser and finasteride in the treatment of androgenetic alopecia(AGA).Methods 80 cases of AGA patients were selected from May 2022 to May 2023 in Tianjin Beichen Hospital,and were divided into 3 groups according to the difference of treatment plans:group A(26 cases)received finasteride treatment,group B(26 cases)received fractional laser and finasteride treatment,and group C(28 cases)received autologous PRP,fractional laser,and finasteride combined treatment.The clinical efficacy,subjective symptom(greasiness,alopecia,itching,scaling)scores and hair microscopy results(mean hair shaft diameter,mean cuirass ratio,and mean hair density)before and 3 months after treatment were compared among the 3 groups.Results The total clinical effective rate of group C>group B and group A(P<0.05).Three months after treatment,the scores of greasiness,alopecia,itching and scaling in group C<group B<group A(P<0.05).Three months after treatment,the average hair shaft diameter,average cuirass ratio and average hair density of the three groups were improved,and the average hair shaft diameter and average hair density of group C was>group B and group A,while the average cuirass ratio was<group B and group A(P<0.05).Conclusion The combination of autologous PRP,fractional laser,and finasteride is effective in the treatment of AGA and can effectively improve the clinical symptoms of patients.