长余辉基适配体传感器在食品安全检测中的应用进展

Progress in the Application of Persistent Luminescence Nanoparticles-based Aptasensors for Food Safety Detection

食品工业的迅速发展离不开安全体系的构建。食品安全检测关系经济民生,是分析领域的研究热点。长余辉纳米粒子具有免原位激发和磷光可再生性,在激发光停止后持续发光,从而消除背景荧光干扰,是理想的光学传感元件。适配体是具有识别性能的寡核苷酸序列,兼具快速响应性、高特异性和灵敏度。二者通过基团键合可构建性能独特的探针,产生靶标刺激的信号变化,在食品安全检测领域享有壮阔前景。本文阐述了近年来长余辉基适配体传感器在食品安全检测中的研究进展。重点聚焦于实现传感器光学激活的设计策略,简要介绍了相应原理的研究应用,最后对于该技术面临的挑战和机遇进行讨论和展望,以推进食品安全检测的发展。

The rapid development of the food industry is inseparable from the construction of a safety system.Food safety detection is of great relevance to the economy and people's livelihood,and is a research hotspot in the field of analytical chemistry.Persistent luminescence nanoparticles(PLNPs)are ideal optical materials that can store excitation energy and emit long-lasting and reproducible luminescence after ceasing excitation.Such unique properties permit autofluorescence-free luminescent sensing.Aptamers are oligonucleotide sequences with recognition properties,fast response and high specificity and sensitivity.The bonding of the two groups allows the construction of probes with unique properties that produce signal changes in response to target stimuli and hold great promise for food safety testing.Therefore,the design principles and the recent progress of PLNPs-based aptasensors for food safety detection developed in recent years are summarized in this paper.The focus is on design strategies to achieve optical activation of the sensors,a brief introduction to the research applications of the corresponding principles,and the challenges and opportunities of this technology are also discussed to promote the development of food safety detection.