肠道菌群通过调节肿瘤微环境影响肝癌的发生

Intestinal flora affects occurrence of hepatocellular carcinoma by regulating tumor microenvironment

目的就肠道菌群对肿瘤微环境的作用以及二者对肝细胞癌(简称肝癌)发生发展的影响进行综述,以期为肝癌发生与发展的原因提供新的思路。方法检索近年来肠道菌群及肿瘤微环境与肝癌关系的相关文献以及肠道菌群与肿瘤微环境关系的相关文献并进行总结。结果肿瘤微环境在肝癌的发生、发展、术后复发等方面起着重要的作用。而肠道菌群作为肿瘤微环境的重要调节因素之一,除了通过肠道-肝脏轴与肝脏相互作用外,还可以通过影响肿瘤微环境诱导肝癌的发生。结论肠道菌群可以通过调节肿瘤微环境来影响肝癌的发生,其具体作用机制仍需进一步研究,这可以作为肝癌研究的新方向。

Objective To review the role of intestinal flora on the tumor microenvironment and the effect of both on the development of hepatocellular carcinoma(HCC),with a view to providing new ideas on the causes of HCC development and progression.Method Relevant articles in the direction of intestinal flora and tumor microenvironment and HCC as well as the relationship between intestinal flora and tumor microenvironment in recent years were searched and summarized.Results The tumor microenvironment played an important role in the occurrence,development and postoperative recurrence of HCC.The intestinal flora,as one of the important regulators of tumor microenvironment,could induce HCC by affecting the tumor microenvironment in addition to interacting with the liver through the gut-liver axis.Conclusion Intestinal flora can influence to HCC by regulating the tumor microenvironment,and its specific mechanism of action still needs to be further investigated,which can be a new direction for HCC research.