鸽子位置细胞筛选及影响因素分析

Screening of place cell and analysis of its influencing factors for pigeons

具有位置调谐特性的位置细胞对于大脑空间认知和导航具有重要作用,但如何筛选位置细胞尚缺乏系统研究。针对位置细胞筛选,以鸽子为模式动物,利用自由活动状态下鸽子海马区锋电位和运动轨迹信号,给出了鸽子位置细胞的筛选流程,分析了位置细胞筛选过程中网格数和滤波核尺寸对于位置细胞位置野的影响。实测和仿真数据结果表明,该筛选方法可以有效地筛选出位置细胞,位置细胞位置野大小在整体趋势上与划分网格数基本呈反比,与高斯滤波核尺寸基本呈正比。该研究不仅能够促进鸽子位置细胞响应特性研究,而且有助于空间认知与导航神经机制的解析。

Place cell with location tuning characteristics play an important role in brain spatial cognition and navigation,but there is relatively little research on place cell screening and its influencing factors.Taking pigeons as model animals,the screening process of pigeon place cell was given by using the spike signal in pigeon hippocampus under free activity.The effects of grid number and filter kernel size on the place field of place cells during the screening process were analyzed.The results from the real and simulation data showed that the proposed place cell screening method presented in this study could effectively screen out place cell,and the research found that the size of place field was basically inversely proportional to the number of grids divided,and was basically proportional to the size of Gaussian filter kernel in the overall trend.This result will not only help to determine the appropriate parameters in the place cell screening process,but also promote the research on the neural mechanism of spatial cognition and navigation of birds such as pigeons.