老年肌少症综合干预循证临床实践指南

Comprehensive intervention for sarcopenia among older adults:an evidence-based clinical practice guideline

肌少症是一种与增龄相关的骨骼肌减少性疾病,可导致老年人功能障碍、跌倒、骨折和死亡等不良后果。及时干预对预防失能和减少住院并发症至关重要。本指南由国家老年疾病临床医学研究中心发起,根据国际标准流程制订,涵盖提出临床问题、确定重要的结局、检索证据和系统评价步骤,并采用推荐分级的评估、制订与评价(GRADE)框架评估证据。最后,课题专家组基于证据进行讨论,形成推荐意见,旨在为老年肌少症患者治疗方案的选择提供参考。

Sarcopenia,characterized by the progressive loss of muscle mass and function,predominantly afflicts older adults.This condition is a notable risk factor for functional impairments,increased incidence of falls and fractures,and can escalate to mortality.Timely intervention is crucial to mitigate disability and minimize complications during hospitalization.The development of these guidelines adhered to an internationally recognized standard protocol.This involved framing clinical queries,pinpointing key outcomes,systematically gathering evidence,and appraising this evidence through the Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)framework.Subsequently,a consortium of experts convened to deliberate over the evidence,culminating in the formulation of these recommendations.