孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床价值分析

Clinical Value Analysis of Montelukast Sodium in the Treatment of Cough Variant Asthma in Children

目的探讨孟鲁司特钠治疗小儿咳嗽变异性哮喘对小儿咳嗽变异性哮喘(cough varian asthma,CVA)复发情况及生活质量的影响。方法选取2020年3月—2022年3月珠海市妇幼保健院96例咳嗽变异性哮喘患儿,以入院顺序不同分为2组,各48例。对照组采用常规治疗;干预组在常规治疗的条件上联合孟鲁司特钠治疗。比较2组治疗效果、咳嗽情况、肺功能、生活质量、CVA复发情况。结果干预组有效率为93.8%,对照组为83.4%,研究组有效率高于对照组(P<0.05);干预组日间、夜间咳嗽评分更低(P<0.05);干预组肺功能更高(P<0.05);干预组生活质量更高(P<0.05);干预组CVA复发情况更少(P<0.05);干预组CVA复发率为2.1%,对照组复发率为14.6%,干预组复发率低于对照组(χ^(2)=7.512,P<0.05)。结论孟鲁司特钠治疗小儿咳嗽变异性哮喘,能够获得比较良好的临床疗效,能够进一步的减小患儿疾病复发风险,改善预后。

Objective To explore the effect of montelukast sodium treatment on the recurrence and quality of life of cough variant asthma(CVA)in children.Methods A total of 96 children with cough-variant asthma from Zhuhai Center for Maternal and Child Health Care,from March 2020 to March 2022,were divide into two groups based on different admission orders,with 48 cases in each group.The control group received routine treatment,while the intervention group received combined with montelukast sodium under conventional treatment conditions.The treatment effectiveness,cough status,lung function,quality of life,and CVA recurrence between the two groups were compared.Results The effective rate of the intervention group was 93.8%,while the effective rate of the control group was 83.4%.The effective rate of the study group was higher than that of the control group(P<0.05).The intervention group had lower daytime and nighttime cough scores(P<0.05).The intervention group had higher lung function(P<0.05).The intervention group had higher quality of life(P<0.05).The intervention group had less recurrence of CVA(P<0.05).The recurrence rate of CVA in the intervention group was 2.1%,while in the control group it was 14.6%.The recurrence rate in the intervention group was lower than that in the control group(χ^(2)=7.512,P<0.05).Conclusion Montelukast sodium in the treatment of children with cough variant asthma can obtain relatively good clinical efficacy,can further reduce the risk of disease recurrence in children,improve the prognosis,and has high application value.