基于纳米颗粒递送系统治疗脓毒症的研究进展

Progress of Research on Nanoparticle-based Delivery System for the Treatment of Sepsis

脓毒症是当今全球治疗最棘手的危重症之一。早期、足量使用敏感抗生素及升压、补液等对症治疗是当前指南推荐的主流治疗方式。然而因脓毒症本身的复杂病理生理机制与日益增长的抗生素耐药性,脓毒症病死率仍高达30%~50%。纳米药物递送技术的快速发展为脓毒症治疗带来新的曙光。文章综述了当今研究的几类主要的纳米颗粒,以及这些纳米颗粒治疗脓毒症的最新进展。

Sepsis is one of the most intractable critical illnesses worldwide.Early and adequate administration of sensitive antibiotics and symptomatic treatments such as vasopressors and fluid resuscitation are the prevalent treatments recommended by the current guidelines.However,due to the complex pathophysiological mechanism of sepsis and increasing antibiotic resistance,the mortality of sepsis reaches up to 30%-50%.The rapid development of nano-drug delivery technology has shed light on promising effectiveness on treatment of sepsis.In this review,several main types of nanoparticles researched today and the latest progress of these nanoparticles in the treatment of sepsis are reviewed.