复方甘草酸苷联合恩替卡韦治疗对乙肝肝硬化外周免疫功能和血清炎症介质的影响

Effects of Compound Glycyrrhizin Combined with Entecavir on Peripheral Immune Function and Serum Inflammatory Mediators in Patients with Hepatitis B Cirrhosis

目的:观察复方甘草酸苷联合恩替卡韦治疗对乙肝肝硬化外周免疫功能和血清炎症介质的影响。方法:选取烟台市北海医院消化内科2022年3月—2023年7月收治的88例乙肝肝硬化患者,按照随机数字表法分为研究组和对照组,对照组(44例)采用恩替卡韦治疗,研究组(44例)在对照组基础上联用复方甘草酸苷治疗,比较两组方案的临床疗效。结果:研究组治疗总有效率、乙肝病毒脱氧核糖核酸(HBV-DNA)转阴率、治疗结束后3 d的CD3^(+)、CD4^(+)和血清白蛋白(ALB)水平均高于对照组,且治疗结束后3 d的Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)、透明质酸(HA)、降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)、总胆红素(TBIL)、谷丙转氨酶(ALT)与谷草转氨酶(AST)水平及不良反应发生率均低于对照组(P<0.05)。结论:复方甘草酸苷联合恩替卡韦治疗乙肝肝硬化效果较好,可有效缓解患者肝功能损伤,抑制肝纤维化进程,减轻炎症刺激,改善临床症状和外周免疫功能表现,治疗安全性和实用性较高。

Objective:To observe the effect of Compound Glycyrrhizin combined with Entecavir on peripheral immune function and serum inflammatory mediators in patients with hepatitis B cirrhosis.Method:Eighty eight patients with hepatitis B cirrhosis admitted to the Department of Gastroenterology,Beihai Hospital of Yantai from March 2022 to July 2023 were selected and divided into the study group and the control group according to the random number table.The control group(44 cases)was treated with Entecavir,and the study group(44 cases)was treated with Compound Glycyrrhizin on the basis of the control group,and the clinical efficacy of the two groups was compared.Result:The total effective rate,negative rate of hepatitis B virus deoxyribonucleic acid(HBV-DNA),CD3^(+),CD4^(+)and serum albumin(ALB)levels 3 days after treatment in the study group were higher than those in the control group,and the levels of collagen Ⅳ(Ⅳ-C),laminin(LN),hyaluronic acid(HA),procalcitonin(PCT),C reactive protein(CRP),white blood cell count(WBC),total bilirubin(TBIL),alanine aminotransferase(ALT)and aspartate aminotransferase(AST)3 days after treatment,as well as the incidence of adverse reactions in the study group were lower than those in the control group(P<0.05).Conclusion:Compound Glycyrrhizin combined with Entecavir is effective in the treatment of hepatitis B cirrhosis,which can effectively alleviate the liver function injury of patients,inhibit the process of liver fibrosis,reduce inflammatory stimulation,improve clinical symptoms and peripheral immune function,and has high safety and practicality.