规律运动在防治COVID-19中的研究进展

Research Progress of Regular Exercise in the Prevention and Treatment of COVID-19

新型冠状病毒病(coronavirus disease-19,COVID-19)是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的以呼吸系统症状为主的疾病。多项研究证明,规律运动对预防COVID-19、增强治疗效果、避免不良预后具有重要作用。本文梳理了运动在COVID-19防治前、中、后的作用及可能机制,运动可通过调节ACE2/Ang(1-7)/Mas轴、增强免疫力和心肺功能、抑制炎症因子和氧化应激、调节肠道菌群稳态以及改善心理状态等途径发挥作用,进而总结出COVID-19防治不同阶段的运动处方,在对运动防治COVID-19全面总结的同时,也为后疫情时代类似呼吸道传染疾病的预防和治疗提供借鉴和参考。

Coronavirus disease-19(COVID-19)is a disease mainly characterized by respiratory symptoms caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Research evidence has indicated that regular exercise plays an important role in preventing COVID-19,enhancing therapeutic effectiveness,and avoiding adverse prognosis.This article reviews the effects and mechanisms of exercise before,during and after the prevention and treatment of COVID-19.Exercise plays its role through regulating the ACE2/Ang(1-7)/Mas axis,enhancing immunity and cardiopulmonary function,inhibiting inflammatory factors and oxidative stress,regulating intestinal flora homeostasis,and improving psychological well-being.Additionally,we summarize the exercise prescriptions for different stages of COVID-19 prevention and treatment.By comprehensively summarizing the role of exercise in the prevention and treatment of COVID-19,we also aim to provide references for the prevention and treatment of similar respiratory infectious diseases in the post-pandemic era.