异基因造血干细胞移植术后肝损伤的诊治进展

Diagnosis and treatment progress of liver injury after allogeneic hematopoietic stem cell transplantation

异基因造血干细胞移植(allo-HSCT)是目前治愈多种血液系统疾病的有效手段。随着移植技术优化,allo-HSCT的临床应用日趋成熟。肝损伤是移植术后常见并发症之一,严重影响患者的生命质量和长期生存。allo-HSCT术后出现肝损伤原因通常可分为非感染性因素和感染性因素,二者临床表现类似,但治疗原则各异。及时诊断移植后肝损伤并鉴别其病因,有助于早期启动预防或针对性治疗,改善患者预后。文章就allo-HSCT术后肝损伤常见病因、临床特点及治疗方案进行综述,旨在加深血液科医师对allo-HSCT术后肝损伤的认识。

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is a curative method for various hematological diseases.With the optimization of transplantation technology,the clinical application of allo-HSCT is more and more mature.Post-transplant liver injury is one of the common postoperative complications,which seriously affects the quality of life and long-term survival of patients.The causes of liver injury after allo-HSCT can be divided into non-infectious and infectious factors,which show similar clinical manifestations and different treatment principles.Timely diagnosis of post-transplant liver injury and the identification of the disease cause will be beneficial for early prevention or targeted treatment,thereby improving patients'prognosis.This review focuses on the etiology,clinical features,and treatment options of liver injury after allo-HSCT,aiming to deepen the understanding of hematologists on liver injury after allo-HSCT.